Gene Symbol | TRMT5 |
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Entrez Gene | 57570 |
Alt Symbol | KIAA1393, TRM5 |
Species | Human |
Gene Type | protein-coding |
Description | tRNA methyltransferase 5 |
Other Description | M1G-methyltransferase|TRM5 tRNA methyltransferase 5 homolog|tRNA (guanine(37)-N1)-methyltransferase|tRNA (guanine-N(1)-)-methyltransferase|tRNA [GM37] methyltransferase|tRNA-N1G37 methyltransferase |
Swissprots | B2RN19 Q9P2F4 Q32P41 |
Accessions | EAW80792 Q32P41 AB037814 BAA92631 AK293158 BAG56703 BC029638 BC063551 BC108284 AAI08285 BC136606 AAI36607 BC136607 AAI36608 BQ050607 DB448202 DC370229 XM_005267916 XP_005267973 XM_011537017 XP_011535319 NM_020810 NP_065861 |
Function | Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. |
Subcellular Location | Mitochondrion matrix {ECO:0000255|HAMAP- Rule:MF_03152}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03152}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03152}. Note=Predominantly in the mitochondria and in the nucleus. {ECO:0000255|HAMAP- Rule:MF_03152}. |
TRMT5 CRISPR/Cas9 KO Plasmid (h) - sc-412838 from Santa Cruz Biotechnology
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TRMT5 HDR Plasmid (h) - sc-412838-HDR from Santa Cruz Biotechnology
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TRMT5 Double Nickase Plasmid (h) - sc-412838-NIC from Santa Cruz Biotechnology
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TRMT5 Double Nickase Plasmid (h2) - sc-412838-NIC-2 from Santa Cruz Biotechnology
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TRMT5 CRISPR Activation Plasmid (h) - sc-412838-ACT from Santa Cruz Biotechnology
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TRMT5 CRISPR Activation Plasmid (h2) - sc-412838-ACT-2 from Santa Cruz Biotechnology
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TRMT5 Lentiviral Activation Particles (h) - sc-412838-LAC from Santa Cruz Biotechnology
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TRMT5 Lentiviral Activation Particles (h2) - sc-412838-LAC-2 from Santa Cruz Biotechnology
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TRMT5 siRNA (h) - sc-92452 from Santa Cruz Biotechnology
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TRMT5 shRNA Plasmid (h) - sc-92452-SH from Santa Cruz Biotechnology
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TRMT5 shRNA (h) Lentiviral Particles - sc-92452-V from Santa Cruz Biotechnology
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TRMT5 RNAi - H00057570-R01 from Novus Biologicals
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MISSION® esiRNA - EHU129761 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22040 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22040 from Sigma-Aldrich
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TRMT5 siRNA (Human) - CRJ1545 from Cohesion Biosciences
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TRMT5 - MBS826907 from MyBioSource
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shRNA set against Human TRMT5 (NM_020810.2) - SHH435332 from Creative biogene
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shRNA set against Human TRMT5(NM_020810.2) - SHL095970 from Creative biogene
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TRMT5 shRNA Plasmid (Human) - CHJ1545 from Cohesion Biosciences
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TRMT5 miRNA 3'UTR clone - MiUTR1H-10774 from Creative biogene
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