KCNN2

Gene Symbol KCNN2
Entrez Gene 3781
Alt Symbol KCa2.2, SK2, SKCA2, SKCa 2, hSK2
Species Human
Gene Type protein-coding
Description potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
Other Description apamin-sensitive small-conductance Ca2+-activated potassium channel|potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2|small conductance calcium-activated potassium channel 2|small conductance calcium-activated potassium channel protein 2
Swissprots Q6X2Y2 Q0VFZ4 Q6PJI0 A6NF94 Q9H2S1
Accessions EAW48975 EAW48976 Q9H2S1 AF239613 AAG16728 AF397175 AAK84039 AK090521 AK289948 BAF82637 AY258141 AAP45946 BC015371 AAH15371 BC040722 BC117454 AAI17455 BC117456 AAI17457 BG477734 BG769522 XM_011543387 XP_011541689 XM_011543388 XP_011541690 XM_011543389 XP_011541691 NM_001278204 NP_001265133 NM_021614 NP_067627 NM_170775 NP_740721 NR_103458
Function Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Expressed in atrial myocytes (at protein level). Widely expressed. {ECO:0000269|PubMed:13679367}.
Top Pathways Bile secretion

KCNN2 (U-24) - sc-101991 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
KCNN2 (U-24): sc-101991. Western blot analysis of KCNN2 expression in Hep G2 whole cell lysate.

Anti-KCNN2 antibody - C-terminal - ab83733 from Abcam

Host Rabbit
Clonality Polyclonal
ICC/IF image of ab83733 stained SKNSH cells. The cells were 4% formaldehyde (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab83733, 0.1µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899 Dylight 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-KCNN2 Antibody (aa443-492) - LS-C31753 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HepG2 Cell Lysate

Anti-KCNN2 Antibody (aa72-121) - LS-C101548 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Lane: Fetal Muscle Lysate

Anti-KCNN2 Antibody (aa545-557) IHC-plus™ - LS-B4408 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-KCNN2 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4408 concentration 3.75 ug/ml.

Anti-KCNN2 Antibody (C-Terminus) IHC-plus™ - LS-A9578 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KCNN2 antibody LS-A9578 IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

KCNN2 Antibody - NBP1-46119 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: KCNN2 Antibody [NBP1-46119] - (0.3ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

KCNN2 Antibody - NBP1-30718 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KCNN2 Antibody - NBP1-83187 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: KCNN2 Antibody [NBP1-83187] - Staining of human duodenum shows strong cytoplasmic positivity in glandular cells.

Anti-KCNN2 antibody produced in goat - SAB2501396 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-KCNN2 <B>Cat. No. SAB2501396</B>: (0.3 μg/mL) staining of Human Liver lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-KCNN2 antibody produced in rabbit - HPA038221 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-KCNN2: <B>Cat. No. HPA038221</B>: Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in glandular cells.

Anti-KCNN2 antibody produced in rabbit - SAB2101228 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-KCNN2: <B>Cat. No.SAB2101228</B>: KCNN2 in Fetal Muscle tissue lysate with KCNN2 antibody at 1.0 μg/mL.

KCNN2 antibody - C-terminal region (ARP35094_T100) - ARP35094_T100 from Aviva Systems Biology

Prices $229.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KCNN2 antibody - middle region (ARP35439_P050) - ARP35439_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KCNN2-Antibody - AF2211a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF2211a (0.3 µg/ml) staining of Human Liver lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

KCNN2 antibody, C-term - GTX49068 from GeneTex

Prices $319.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal

KCNN2 antibody, Internal - GTX88269 from GeneTex

Prices $329.00
Sizes 100 μg
Host Goat
Clonality Polyclonal
Anti-KCNN2 antibody, Internal used in IHC (Formalin-fixed paraffin-embedded sections). GTX88269

KCNN2 Antibody (OAEB02099) - OAEB02099 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti -KCNN2 (HSK2, KCa2.2, Sk2, SKCA2, SKCa 2) - 170895 from USBiological Life Science

Host Rabbit
Clonality Polyclonal

KCNN2 Antibody (OALA01591) - OALA01591 from Aviva Systems Biology

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

KCNN2 antibody - AP10032PU-N from Acris Antibodies

Prices $330.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AP10032PU-N KCNN2 antibody staining of Paraffin Embedded Human Thyroid Gland at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Anti-KCNN2 Antibody - AC21-2013 from Abcore

Prices $359.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-KCNN2 Antibody (AMCA) - AC21-2013-01 from Abcore

Prices $495.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-KCNN2 Antibody (AP) - AC21-2013-02 from Abcore

Prices $505.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-KCNN2 Antibody (APC) - AC21-2013-03 from Abcore

Prices $515.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
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