| Gene Symbol |
KCNN2
|
| Entrez Gene |
3781
|
| Alt Symbol |
KCa2.2, SK2, SKCA2, SKCa 2, hSK2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
|
| Other Description |
apamin-sensitive small-conductance Ca2+-activated potassium channel|potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2|small conductance calcium-activated potassium channel 2|small conductance calcium-activated potassium channel protein 2
|
| Swissprots |
Q6X2Y2 Q0VFZ4 Q6PJI0 A6NF94 Q9H2S1
|
| Accessions |
EAW48975 EAW48976 Q9H2S1 AF239613 AAG16728 AF397175 AAK84039 AK090521 AK289948 BAF82637 AY258141 AAP45946 BC015371 AAH15371 BC040722 BC117454 AAI17455 BC117456 AAI17457 BG477734 BG769522 XM_011543387 XP_011541689 XM_011543388 XP_011541690 XM_011543389 XP_011541691 NM_001278204 NP_001265133 NM_021614 NP_067627 NM_170775 NP_740721 NR_103458
|
| Function |
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed in atrial myocytes (at protein level). Widely expressed. {ECO:0000269|PubMed:13679367}.
|
| Top Pathways |
Bile secretion
|
![Western Blot: KCNN2 Overexpression Lysate (Adult Normal) [NBP2-06528] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KCNN2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4782_KCNN2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06528-img0001.jpg)