KCNN2
| Gene Symbol | KCNN2 |
|---|---|
| Entrez Gene | 3781 |
| Alt Symbol | KCa2.2, SK2, SKCA2, SKCa 2, hSK2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 |
| Other Description | apamin-sensitive small-conductance Ca2+-activated potassium channel|potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2|small conductance calcium-activated potassium channel 2|small conductance calcium-activated potassium channel protein 2 |
| Swissprots | Q6X2Y2 Q0VFZ4 Q6PJI0 A6NF94 Q9H2S1 |
| Accessions | EAW48975 EAW48976 Q9H2S1 AF239613 AAG16728 AF397175 AAK84039 AK090521 AK289948 BAF82637 AY258141 AAP45946 BC015371 AAH15371 BC040722 BC117454 AAI17455 BC117456 AAI17457 BG477734 BG769522 XM_011543387 XP_011541689 XM_011543388 XP_011541690 XM_011543389 XP_011541691 NM_001278204 NP_001265133 NM_021614 NP_067627 NM_170775 NP_740721 NR_103458 |
| Function | Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. |
| Subcellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Specificity | Expressed in atrial myocytes (at protein level). Widely expressed. {ECO:0000269|PubMed:13679367}. |
| Top Pathways | Bile secretion |
KCNN2 CRISPR/Cas9 KO Plasmid (h) - sc-405381 from Santa Cruz Biotechnology
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KCNN2 HDR Plasmid (h) - sc-405381-HDR from Santa Cruz Biotechnology
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KCNN2 Double Nickase Plasmid (h) - sc-405381-NIC from Santa Cruz Biotechnology
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KCNN2 Double Nickase Plasmid (h2) - sc-405381-NIC-2 from Santa Cruz Biotechnology
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KCNN2 CRISPR Activation Plasmid (h) - sc-405381-ACT from Santa Cruz Biotechnology
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KCNN2 CRISPR Activation Plasmid (h2) - sc-405381-ACT-2 from Santa Cruz Biotechnology
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KCNN2 Lentiviral Activation Particles (h) - sc-405381-LAC from Santa Cruz Biotechnology
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KCNN2 Lentiviral Activation Particles (h2) - sc-405381-LAC-2 from Santa Cruz Biotechnology
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KCNN2 siRNA (h) - sc-91889 from Santa Cruz Biotechnology
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KCNN2 shRNA Plasmid (h) - sc-91889-SH from Santa Cruz Biotechnology
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KCNN2 shRNA (h) Lentiviral Particles - sc-91889-V from Santa Cruz Biotechnology
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KCNN2 RNAi - H00003781-R02 from Novus Biologicals
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MISSION® esiRNA - EHU150121 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10982 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10982 from Sigma-Aldrich
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KCNN2 siRNA (Human) - CRH2555 from Cohesion Biosciences
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KCNN2 RNAi - H00003781-R01 from Novus Biologicals
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shRNA set against Human KCNN2 (NM_021614.2) - SHH323599 from Creative biogene
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shRNA set against Human KCNN2(NM_021614.2) - SHL190956 from Creative biogene
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shRNA set against Human KCNN2(NM_170775.1) - SHL190974 from Creative biogene
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Human KCNN2 siRNA - orb263057 from Biorbyt
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KCNN2 shRNA Plasmid (Human) - CHH2555 from Cohesion Biosciences
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KCNN2 miRNA 3'UTR clone - MiUTR1H-05160 from Creative biogene
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KCNN2 miRNA 3'UTR clone - MiUTR1H-05161 from Creative biogene
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