| Gene Symbol |
TAAR5
|
| Entrez Gene |
9038
|
| Alt Symbol |
PNR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
trace amine associated receptor 5
|
| Other Description |
hTaar5|putative neurotransmitter receptor|taR-5|trace amine receptor 5|trace amine-associated receptor 5
|
| Swissprots |
Q5VUQ3 D8KZS1 Q4VBL1 O14804 Q2M1V1 Q6NTA8
|
| Accessions |
AAV70123 ACP18682 EAW48025 O14804 AF021818 AAC39581 BC069171 AAH69171 BC095541 AAH95541 BC112209 AAI12210 BC112211 AAI12212 NM_003967 NP_003958
|
| Function |
Olfactory receptor specific for trimethylamine, a trace amine. Also activated at lower level by dimethylethylamine. Trimethylamine is a bacterial metabolite found in some animal odors, and to humans it is a repulsive odor associated with bad breath and spoiled food. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase. {ECO:0000269|PubMed:23393561}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:23393561}; Multi-pass membrane protein {ECO:0000269|PubMed:23393561}.
|
| Tissue Specificity |
Expressed almost exclusively in skeletal muscle and selected areas of the brain, such amygdala, hippocampus, caudate nucleus, thalamus and hypothalamus. Weak expression is also find in substantia nigra. {ECO:0000269|PubMed:9464258}.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|