Gene Symbol |
NET1
|
Entrez Gene |
10276
|
Alt Symbol |
ARHGEF8, NET1A
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
neuroepithelial cell transforming 1
|
Other Description |
Rho guanine nucleotide exchange factor (GEF) 8|guanine nucleotide regulatory protein (oncogene)|neuroepithelial cell-transforming gene 1 protein|neuroepithelioma transforming gene 1|p65 Net1 proto-oncogene protein|small GTP-binding protein regulator
|
Swissprots |
Q99903 Q9UEN6 Q7Z628 Q12773 Q96D82
|
Accessions |
EAW86445 EAW86446 Q7Z628 AB209852 BAD93089 AJ010046 CAA08974 AK024919 AK294244 BAG57540 AK299335 BAG61338 AK302687 BAG63916 AK304028 BAG64943 AK315566 BAG37941 BC010285 AAH10285 BC053553 AAH53553 BP354878 BQ024592 BU633004 BX537509 CD722646 DA727151 DB177813 DC307907 S82401 AAB37683 U02081 AAB08847 NM_001047160 NP_001040625 NM_005863 NP_005854 NR_073040
|
Function |
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:21373644}.
|
Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
|
Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:8649828}.
|