Gene Symbol | NET1 |
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Entrez Gene | 10276 |
Alt Symbol | ARHGEF8, NET1A |
Species | Human |
Gene Type | protein-coding |
Description | neuroepithelial cell transforming 1 |
Other Description | Rho guanine nucleotide exchange factor (GEF) 8|guanine nucleotide regulatory protein (oncogene)|neuroepithelial cell-transforming gene 1 protein|neuroepithelioma transforming gene 1|p65 Net1 proto-oncogene protein|small GTP-binding protein regulator |
Swissprots | Q99903 Q9UEN6 Q7Z628 Q12773 Q96D82 |
Accessions | EAW86445 EAW86446 Q7Z628 AB209852 BAD93089 AJ010046 CAA08974 AK024919 AK294244 BAG57540 AK299335 BAG61338 AK302687 BAG63916 AK304028 BAG64943 AK315566 BAG37941 BC010285 AAH10285 BC053553 AAH53553 BP354878 BQ024592 BU633004 BX537509 CD722646 DA727151 DB177813 DC307907 S82401 AAB37683 U02081 AAB08847 NM_001047160 NP_001040625 NM_005863 NP_005854 NR_073040 |
Function | Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:21373644}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:8649828}. |
NET1 CRISPR/Cas9 KO Plasmid (h) - sc-402376 from Santa Cruz Biotechnology
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NET1 HDR Plasmid (h) - sc-402376-HDR from Santa Cruz Biotechnology
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NET1 Double Nickase Plasmid (h) - sc-402376-NIC from Santa Cruz Biotechnology
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NET1 Double Nickase Plasmid (h2) - sc-402376-NIC-2 from Santa Cruz Biotechnology
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NET1 CRISPR Activation Plasmid (h) - sc-402376-ACT from Santa Cruz Biotechnology
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NET1 CRISPR Activation Plasmid (h2) - sc-402376-ACT-2 from Santa Cruz Biotechnology
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NET1 Lentiviral Activation Particles (h) - sc-402376-LAC from Santa Cruz Biotechnology
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NET1 Lentiviral Activation Particles (h2) - sc-402376-LAC-2 from Santa Cruz Biotechnology
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NET1 siRNA (h) - sc-41726 from Santa Cruz Biotechnology
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NET1 shRNA Plasmid (h) - sc-41726-SH from Santa Cruz Biotechnology
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NET1 shRNA (h) Lentiviral Particles - sc-41726-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU059351 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15212 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15212 from Sigma-Aldrich
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NET1 siRNA (Human) - CRH6957 from Cohesion Biosciences
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shRNA set against Human NET1 (NM_005863.4) - SHH351408 from Creative biogene
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Human NET1 siRNA - orb267459 from Biorbyt
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NET1 shRNA Plasmid (Human) - CHH6957 from Cohesion Biosciences
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NET1 miRNA 3'UTR clone - MiUTR3H-08462 from Creative biogene
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NET1 miRNA 3'UTR clone - MiUTR3H-08463 from Creative biogene
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