| Gene Symbol | C1QBP |
|---|---|
| Entrez Gene | 708 |
| Alt Symbol | GC1QBP, HABP1, SF2p32, gC1Q-R, gC1qR, p32 |
| Species | Human |
| Gene Type | protein-coding |
| Description | complement component 1, q subcomponent binding protein |
| Other Description | ASF/SF2-associated protein p32|C1q globular domain-binding protein|complement component 1 Q subcomponent-binding protein, mitochondrial|glycoprotein gC1qBP|hyaluronan-binding protein 1|mitochondrial matrix protein p32|p33|splicing factor SF2-associated protein |
| Swissprots | Q07021 Q2HXR8 Q9NNY8 |
| Accessions | AAK26580 ABC79624 EAW90335 EAW90336 EAW90337 Q07021 AF275902 AAF78763 AJ297362 CAB95947 AK291516 BAF84205 BC000435 AAH00435 BC013731 AAH13731 BT019898 AAV38701 BT019899 AAV38702 DQ891331 ABM82257 DQ893366 ABM84292 DQ894514 ABM85440 DQ896683 ABM87682 L04636 AAA16315 X75913 CAA53512 NM_001212 NP_001203 |
| Function | Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-typ |
| Subcellular Location | Mitochondrion matrix. Nucleus. Cell membrane; Peripheral membrane protein; Extracellular side. Secreted. Cytoplasm. Nucleus, nucleolus. Note=Seems to be predominantly localized to mitochondria. Secreted by activated lymphocytes. |
| Tissue Specificity | Expressed on cell surface of peripheral blood cells (at protein level); Surface expression is reported for macrophages and monocyte-derived dendritic cells. {ECO:0000269|PubMed:12574814, ECO:0000269|PubMed:8662673}. |
| Top Pathways | Herpes simplex infection |
Human GC1qR / C1QBP ELISA Kit (Sandwich ELISA) - LS-F4543 from LifeSpan Bioscience
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Human HABP1 ELISA Kit - abx151769 from Abbexa
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Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP), Human, ELISA Kit - E01C1235 from ARP American Research Products
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Hyaluronan Binding Protein 1, HABP1/C1QBP, Human, ELISA Kit - E-EL-H2534 from ARP American Research Products
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Hyaluronan Binding Protein 1 (HABP1), Human, ELISA Kit - SEA651Hu from ARP American Research Products
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Hyaluronan Binding Protein 1, HABP1, Mouse, ELISA Kit - E-EL-M0683 from ARP American Research Products
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Hyaluronan Binding Protein 1, HABP1, Rat, ELISA Kit - E-EL-R0510 from ARP American Research Products
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Human HABP1 ELISA Kit - HH1224 from NeoScientific
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Human HABP1 ELISA Kit - HH0042 from NeoScientific
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Porcine HABP1 ELISA Kit - PH0042 from NeoScientific
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Anserine HABP1 ELISA Kit - AH0042 from NeoScientific
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Anserine HABP1 ELISA Kit - AH1224 from NeoScientific
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Complement Component 1, Q Subcomponent Like Protein 1 (C1qL1), ELISA Kit - MBS2023244 from MyBioSource
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ELISA Kit for Hyaluronan Binding Protein 1 (HABP1) - SEA651Hu from Uscn Life Science Inc.
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Human HABP1/C1QBP(Hyaluronan Binding Protein 1) ELISA Kit - E-EL-H2534 from Elabscience
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Human HABP1/C1QBP (Hyaluronan Binding Protein 1) CLIA Kit - E-CL-H1447 from Elabscience
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Complement component 1 Q subcomponent binding protein, mitochondrial (C1QBP), ELISA Kit - MBS7213525 from MyBioSource
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Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP), ELISA Kit - MBS7237888 from MyBioSource
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Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP), ELISA Kit - MBS7219462 from MyBioSource
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Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP), ELISA Kit - MBS7225410 from MyBioSource
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Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP), ELISA Kit - MBS7241324 from MyBioSource
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Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP), ELISA Kit - MBS7246201 from MyBioSource
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Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP), ELISA Kit - MBS7230847 from MyBioSource
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Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP), ELISA Kit - MBS7238019 from MyBioSource
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Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP), ELISA Kit - MBS7208074 from MyBioSource
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