C1QBP

Gene Symbol C1QBP
Entrez Gene 708
Alt Symbol GC1QBP, HABP1, SF2p32, gC1Q-R, gC1qR, p32
Species Human
Gene Type protein-coding
Description complement component 1, q subcomponent binding protein
Other Description ASF/SF2-associated protein p32|C1q globular domain-binding protein|complement component 1 Q subcomponent-binding protein, mitochondrial|glycoprotein gC1qBP|hyaluronan-binding protein 1|mitochondrial matrix protein p32|p33|splicing factor SF2-associated protein
Swissprots Q07021 Q2HXR8 Q9NNY8
Accessions AAK26580 ABC79624 EAW90335 EAW90336 EAW90337 Q07021 AF275902 AAF78763 AJ297362 CAB95947 AK291516 BAF84205 BC000435 AAH00435 BC013731 AAH13731 BT019898 AAV38701 BT019899 AAV38702 DQ891331 ABM82257 DQ893366 ABM84292 DQ894514 ABM85440 DQ896683 ABM87682 L04636 AAA16315 X75913 CAA53512 NM_001212 NP_001203
Function Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-typ
Subcellular Location Mitochondrion matrix. Nucleus. Cell membrane; Peripheral membrane protein; Extracellular side. Secreted. Cytoplasm. Nucleus, nucleolus. Note=Seems to be predominantly localized to mitochondria. Secreted by activated lymphocytes.
Tissue Specificity Expressed on cell surface of peripheral blood cells (at protein level); Surface expression is reported for macrophages and monocyte-derived dendritic cells. {ECO:0000269|PubMed:12574814, ECO:0000269|PubMed:8662673}.
Top Pathways Herpes simplex infection

C1QBP (D7H12) XP ® Rabbit mAb - 6502 from Cell Signaling Technology

Prices $277.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7H12
Western blot analysis of extracts from various cell lines using C1QBP (D7H12) XP ® Rabbit mAb.

C1QBP Antibody - 5734 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using C1QBP Antibody.

C1QBP (B-6) - sc-271201 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
C1QBP (B-6): sc-271201. Western blot analysis of C1QBP expression in Jurkat (A), HeLa (B) and Ramos (C) whole cell lysates.

C1QBP (L-19) - sc-23278 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
C1QBP (L-19): sc-23278. Western blot analysis of C1QBP expression in MDA-MB-468 (A) and Raji (B) whole cell lysates and MCF7 (C) and HeLa (D) nuclear extracts.

C1QBP (H-9) - sc-271200 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
C1QBP (H-9): sc-271200. Western blot analysis of C1QBP expression in Jurkat (A), HeLa (B) and Ramos (C) whole cell lysates.

C1QBP (D-19) - sc-10258 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
C1QBP (D-19): sc-10258. Western blot analysis of C1QBP expression in non-transfected: sc-110760 (A) and human C1QBP transfected: sc-113035 (B) 293 whole cell lysates.

C1QBP (60.11) - sc-23884 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
C1QBP (60.11): sc-23884. Western blot analysis of C1QBP expression in HL-60 (A) and Hep G2 (B) whole cell lysates.

C1QBP (C-17) - sc-10259 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
C1QBP (C-17): sc-10259. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

C1QBP (20) - sc-136433 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
C1QBP (20): sc-136433. Western blot analysis of C1QBP expression in K-562 whole cell lysate.

C1QBP (K-18) - sc-10257 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
C1QBP (K-18): sc-10257. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic staining.

C1QBP (FL-282) - sc-48795 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
C1QBP (FL-282): sc-48795. Western blot analysis of C1QBP expression in HISM whole cell lysate.

C1QBP (74.5.2) - sc-23885 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
C1QBP (74.5.2): sc-23885. Western blot analysis of C1QBP expression in non-transfected: sc-110760 (A) and human C1QBP transfected: sc-113035 (B) 293 whole cell lysates.

C1QBP (P-19) - sc-23277 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

C1QBP (1.T.22) - sc-70471 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Anti-GC1q R antibody - ab101267 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung carcinoma tissue labelling GC1q R with ab101267 at 1/1000 (1µg/ml).

Anti-GC1q R antibody - ab88591 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-GC1q R antibody (ab88591) at 1 µg/ml + Human liver tissue lysate at 50 µgdeveloped using the ECL technique

Anti-GC1q R antibody - ab101268 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human ovarian carcinoma tissue labelling GC1q R with ab101268 at 1/1000 (1µg/ml).

Anti-GC1q R antibody - ab92702 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GC1q R antibody (ab92702) at 1/500 dilutionLane 1 : extracts from HUVEC cellsLane 2 : extracts from Jurkat cellsLane 3 : extracts from HUVEC cells with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-GC1q R antibody - ab183640 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GC1q R antibody (ab183640) at 1/10000 dilutionLane 1 : NIH 3T3 whole cell lysateLane 2 : JC whole cell lysateLane 3 : BCL1 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-GC1q R antibody - ab133755 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GC1q R antibody (ab133755) at 1/500 dilutionLane 1 : K562 cell extractLane 2 : HuvEc cell extractLane 3 : Jurkat cell extractLane 4 : K562 cell extract plus immunising peptide

Anti-GC1q R antibody - ab135678 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-GC1q R antibody (ab135678) at 1/50 dilution + HepG2 cell line lysates at 35 µg

Anti-GC1q R antibody [60.11] - ab24733 from Abcam

Prices $403.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 60.11
All lanes : Anti-GC1q R antibody [60.11] (ab24733) at 5 µg/mlLane 1 : HEK293 (Human embryonic kidney cell line) Whole Cell Lysate Lane 2 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 3 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate Lane 4 : Raji (Human Burkitt's lymphoma cell line) Whole Cell Lysate Lane 5 : Liver (Human) Tissue Lysate - adult normal tissue (ab29889)Lysates/proteins at 20 µg per lane.SecondaryGoat Anti-Mouse IgG H&L (HRP) preadsorbed (ab97040) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-GC1q R antibody [60.11] - ab106047 from Abcam

Host Mouse
Clonality Monoclonal
Clone 60.11
IHC image of GC1q R staining in human spleen formalin fixed paraffin embedded tissue section, performed on a Leica Bond system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab106047, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-GC1q R antibody [60.11] (FITC) - ab125138 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 60.11

Anti-GC1q R antibody [60.11] (HRP) - ab199987 from Abcam

Prices $425.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 60.11
All lanes : Anti-GC1q R antibody [60.11] (HRP) (ab199987) at 1/5000 dilutionLane 1 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLane 2 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 3 : Raji (Human Burkitt's lymphoma cell line) Whole Cell LysateLane 4 : Liver (Human) Tissue Lysate - adult normal tissueLysates/proteins at 20 µg per lane.developed using the ECL techniquePerformed under reducing conditions.
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