C1QBP

Gene Symbol	C1QBP
Entrez Gene	708
Alt Symbol	GC1QBP, HABP1, SF2p32, gC1Q-R, gC1qR, p32
Species	Human
Gene Type	protein-coding
Description	complement component 1, q subcomponent binding protein
Other Description	ASF/SF2-associated protein p32|C1q globular domain-binding protein|complement component 1 Q subcomponent-binding protein, mitochondrial|glycoprotein gC1qBP|hyaluronan-binding protein 1|mitochondrial matrix protein p32|p33|splicing factor SF2-associated protein
Swissprots	Q07021 Q2HXR8 Q9NNY8
Accessions	AAK26580 ABC79624 EAW90335 EAW90336 EAW90337 Q07021 AF275902 AAF78763 AJ297362 CAB95947 AK291516 BAF84205 BC000435 AAH00435 BC013731 AAH13731 BT019898 AAV38701 BT019899 AAV38702 DQ891331 ABM82257 DQ893366 ABM84292 DQ894514 ABM85440 DQ896683 ABM87682 L04636 AAA16315 X75913 CAA53512 NM_001212 NP_001203
Function	Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-typ
Subcellular Location	Mitochondrion matrix. Nucleus. Cell membrane; Peripheral membrane protein; Extracellular side. Secreted. Cytoplasm. Nucleus, nucleolus. Note=Seems to be predominantly localized to mitochondria. Secreted by activated lymphocytes.
Tissue Specificity	Expressed on cell surface of peripheral blood cells (at protein level); Surface expression is reported for macrophages and monocyte-derived dendritic cells. {ECO:0000269|PubMed:12574814, ECO:0000269|PubMed:8662673}.
Top Pathways	Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human GC1q R full length protein - ab172818 from Abcam Category Protein Source E. coli Species Human

Human GC1q R full length protein - ab78834 from Abcam Category Protein Source E. coli Species Human

Human GC1q R full length protein - ab117655 from Abcam Category Protein Source E. coli Species Human

GC1qR / C1QBP Antibody Blocking Peptide - LS-E9300 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GC1qR / C1QBP Antibody Blocking Peptide - LS-E9301 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HABP1/C1QBP/GC1q R Partial Recombinant Protein - H00000708-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

HABP1/C1QBP/GC1q R Recombinant Protein - H00000708-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg

Recombinant Human HABP1/C1QBP/GC1q R Protein - NBC1-18489 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

HABP1/C1QBP/GC1q R Peptide - P2865 from Novus Biologicals Category Peptide Species Human

HABP1/C1QBP/GC1q R Peptide - P2864 from Novus Biologicals Category Peptide Species Human

C1QBP-Antibody-Center-Blocking-Peptide - BP7839c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GC1qR-C1QBP-Antibody-C-term-Blocking-peptide - BP7839b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human HABP1/C1QBP, CF - 5155-HB-050 from R&D Systems Category Protein Source E. coli-derived, His75-Gln282, with an N-term 2-Met tag and a C-terminal 6-His tag

C1QBP Protein (OPPA01734) - OPPA01734 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human Complement Component 1 protein - orb80975 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Source E.coli

Human HABP1 protein - orb163507 from Biorbyt Category Protein Prices $306.00, $400.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human C1QBP His tag protein - orb84142 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source E. coli Species Human

C1QBP peptide - orb216978 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human

C1QBP protein - 30R-1179 from Fitzgerald Category Protein Prices $295.00 Sizes 100 µg Source E.coli

C1QBP Blocking Peptide - abx062309 from Abbexa Category Peptide Species Human

Human HABP1 Protein - abx067141 from Abbexa Category Protein Source E.coli Species Human

C1QBP (74-282) - AR03040PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

C1QBP (74-282) - AR03040PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

C1QBP - H00000708-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

C1QBP - H00000708-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

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