| Gene Symbol |
LGR5
|
| Entrez Gene |
8549
|
| Alt Symbol |
FEX, GPR49, GPR67, GRP49, HG38
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leucine-rich repeat containing G protein-coupled receptor 5
|
| Other Description |
G-protein coupled receptor 49|G-protein coupled receptor 67|G-protein coupled receptor HG38|leucine-rich repeat-containing G protein-coupled receptor 5|leucine-rich repeat-containing G-protein coupled receptor 5|orphan G protein-coupled receptor HG38
|
| Swissprots |
Q4VAM2 O75473 Q9UP75 Q4VAM0 D8MCT0
|
| Accessions |
CDI30209 CDI30210 CDI30211 CDI30212 EAW97258 EAW97259 O75473 AB105190 BAQ19758 AF061444 AAC77911 AF062006 AAC28019 AK075399 AK294985 BAG58053 AK315133 BC096324 AAH96324 BC096325 AAH96325 BC096326 AAH96326 BC099650 AAH99650 BQ774570 CA412916 DA811892 DC323352 DR003044 FN820440 CBL95002 H88004 XM_005269204 XP_005269261 NM_001277226 NP_001264155 NM_001277227 NP_001264156 NM_003667 NP_003658 NR_110596
|
| Function |
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R- spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23809763}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans- Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653). {ECO:0000269|PubMed:23439653}.
|
| Tissue Specificity |
Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver. {ECO:0000269|PubMed:12601349, ECO:0000269|PubMed:16575208, ECO:0000269|PubMed:19030762}.
|