LGR5

Gene Symbol	LGR5
Entrez Gene	8549
Alt Symbol	FEX, GPR49, GPR67, GRP49, HG38
Species	Human
Gene Type	protein-coding
Description	leucine-rich repeat containing G protein-coupled receptor 5
Other Description	G-protein coupled receptor 49|G-protein coupled receptor 67|G-protein coupled receptor HG38|leucine-rich repeat-containing G protein-coupled receptor 5|leucine-rich repeat-containing G-protein coupled receptor 5|orphan G protein-coupled receptor HG38
Swissprots	Q4VAM2 O75473 Q9UP75 Q4VAM0 D8MCT0
Accessions	CDI30209 CDI30210 CDI30211 CDI30212 EAW97258 EAW97259 O75473 AB105190 BAQ19758 AF061444 AAC77911 AF062006 AAC28019 AK075399 AK294985 BAG58053 AK315133 BC096324 AAH96324 BC096325 AAH96325 BC096326 AAH96326 BC099650 AAH99650 BQ774570 CA412916 DA811892 DC323352 DR003044 FN820440 CBL95002 H88004 XM_005269204 XP_005269261 NM_001277226 NP_001264155 NM_001277227 NP_001264156 NM_003667 NP_003658 NR_110596
Function	Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R- spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23809763}.
Subcellular Location	Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans- Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653). {ECO:0000269|PubMed:23439653}.
Tissue Specificity	Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver. {ECO:0000269|PubMed:12601349, ECO:0000269|PubMed:16575208, ECO:0000269|PubMed:19030762}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GPR49 / LGR5 Antibody Blocking Peptide - LS-E7062 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GPR49 / LGR5 Antibody Blocking Peptide - LS-E7063 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GPR49 / LGR5 Antibody Blocking Peptide - LS-E28193 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

GPR49 / LGR5 Antibody Blocking Peptide - LS-E28194 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

GPR49 / LGR5 Blocking Peptide - LS-E35814 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Lgr5/GPR49 Blocking Peptide - NBP1-28904PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

Lgr5/GPR49 Peptide - P1234 from Novus Biologicals Category Peptide Species Human

LGR5-GPR49-Antibody-Center-Blocking-peptide - BP2745f from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LGR5-Antibody-loop2-Blocking-peptide - BP2745d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Lgr5/GPR49 Fc Chimera, CF - 8078-GP-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

Human LGR5 protein - orb246757 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

LGR5 fusion protein - ag16389 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

LGR5 fusion protein - Ag17162 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human LGR5, Fc Chimera - LGR5-1037H from Creative Biomart Category Protein Source CHO Cells Species Human

Recombinant Human Lgr5/GPR49 Fc Chimera Protein, CF - 8078-GP from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Chinese Hamster Ovary cell line, CHO-derived Human LGR-5/GPR49 (Gly22-Ile560) Accession # O75473 IEGRMD Human IgG 1 (Pro100-Lys330) N-terminus C-terminus Species Human

LGR5 Peptide - abx165051 from Abbexa Category Peptide Species Human, Mouse

LGR5 / GPR49 (C-term Fc tag) - TP700187 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

LGR5GPR49-Antibody-loop1-Blocking-peptide - BP11867a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LGR5-GPR49-Antibody-loop1-Blocking-peptide - BP2745c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LGR5-GPR49-Antibody-C-term-Blocking-peptide - BP2745b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LGR5GPR49-Antibody-N-term-Blocking-Peptide - BP2745a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LGR5 Peptide, Human - M34GP08674H from Creative Peptides Category Peptide Source Synthetic. Species Human

LGR5 Recombinant Protein (OPCA02708) - OPCA02708 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Lgr5 protein - orb86156 from Biorbyt Category Protein Prices $238.00 Sizes 500 µg

Recombinant Human Leucine-rich repeat-containing G-protein coupled receptor 5(LGR5),partial - CSB-YP012906HU from Cusabio Category Protein Source Yeast Species Human

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