CCRL2

Gene Symbol CCRL2
Entrez Gene 9034
Alt Symbol ACKR5, CKRX, CRAM, CRAM-A, CRAM-B, HCR
Species Human
Gene Type protein-coding
Description chemokine (C-C motif) receptor-like 2
Other Description C-C chemokine receptor-like 2|atypical chemokine receptor 5|chemokine receptor CCR11|chemokine receptor X|putative MCP-1 chemokine receptor
Swissprots O00421 Q4VBB0 O75307 Q96KP5 Q7KYQ9 B4DKQ8 Q6IPX0 Q9UPG0
Accessions AAB57794 CAH60289 CAJ15094 CAJ15095 EAW64765 EAW64766 O00421 AF015524 AAC34601 AF015525 AAC34602 AJ344142 CAC82985 AK296673 BAG59270 AK313312 BAG36117 BC071682 AAH71682 BC096075 AAH96075 BC096076 AAH96076 DC387981 DQ892102 ABM83028 DQ895296 ABM86222 XM_011534208 XP_011532510 XM_011534209 XP_011532511 NM_001130910 NP_001124382 NM_003965 NP_003956
Function Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.
Subcellular Location Cell membrane {ECO:0000269|PubMed:18397265, ECO:0000269|PubMed:20002784}; Multi-pass membrane protein {ECO:0000269|PubMed:18397265, ECO:0000269|PubMed:20002784}.
Tissue Specificity Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T- cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B-cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients. {ECO:0000269|PubMed:11828366, ECO:0000269|PubMed:15188357, ECO:0000269|PubMed:18397265, ECO:0000269|PubMed:9473515}.

CCRL2 (F-12) - sc-102422 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
CCRL2 (F-12): sc-102422. Western blot analysis of CCRL2 expression in K-562 whole cell lysate.

CCRL2 (S-12) - sc-102423 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
CCRL2 (S-12): sc-102423. Western blot analysis of CCRL2 expression in K-562 whole cell lysate.

Anti-CCRL2 antibody - ab88632 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
FACS analysis of negative control 293 cells (black) and CCRL2-expressing 293 cells (green) using ab88632.

Anti-CCRL2 antibody - ab129620 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-CCRL2 antibody (ab129620) at 1/100 dilution + 293 cell line lysates at 35 µgdeveloped using the ECL technique

Anti-CCRL2 antibody - ab136057 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CCRL2 antibody (ab136057) at 1/500 dilution + 293 cell lysates at 30 µg

Anti-CCRL2 antibody - ab85224 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CCRL2 antibody (ab85224) at 1 µg/ml (in 5% skim milk / PBS buffer) + 721_B Cell Lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-CCRL2 antibody [1B2] - ab167114 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1B2
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human placenta tissue labeling CCRL2 with ab167114 at 8 µg/ml.

Anti-CCRL2 antibody [MM0158-5A15] - ab89547 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0158-5A15

Anti-CCRL2 antibody - Cytoplasmic domain - ab140775 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin embedded Human spleen tissue labelling CCRL2 with ab140775 at 8 µg/ml.

Anti-CCRL2 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A1094 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CCRL2 antibody LS-A1094 IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CCRL2 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A1093 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CCRL2 antibody LS-A1093 IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CCRL2 Antibody (clone 12K19, APC) - LS-C182778 from LifeSpan Bioscience

Prices $635.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal
Clone 12K19

Anti-CCRL2 Antibody (clone 12K19, PE) - LS-C182779 from LifeSpan Bioscience

Prices $575.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal
Clone 12K19

Anti-CCRL2 Antibody (aa206-234, AP) - LS-C253832 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCRL2 Antibody (aa206-234, APC) - LS-C253834 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCRL2 Antibody (aa206-234, Biotin) - LS-C253835 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCRL2 Antibody (aa206-234, FITC) - LS-C253836 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCRL2 Antibody (aa36-85) - LS-C101475 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CCRL2 antibody LS-C101475 Western blot of 721_B cell lysate.

Anti-CCRL2 Antibody (aa206-234, PE) - LS-C253840 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCRL2 Antibody (aa206-234, Azide-free, HRP) - LS-C253837 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCRL2 Antibody (aa132-181) - LS-C291763 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CCRL2 Antibody - LS-C306795 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-CCRL2 Antibody (aa191-236) - LS-C313698 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CCRL2 Antibody (aa141-190) - LS-C120560 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of COS7 cells, using CCRL2 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-CCRL2 Antibody (aa205-234) - LS-C320136 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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