| Gene Symbol |
CCRL2
|
| Entrez Gene |
9034
|
| Alt Symbol |
ACKR5, CKRX, CRAM, CRAM-A, CRAM-B, HCR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chemokine (C-C motif) receptor-like 2
|
| Other Description |
C-C chemokine receptor-like 2|atypical chemokine receptor 5|chemokine receptor CCR11|chemokine receptor X|putative MCP-1 chemokine receptor
|
| Swissprots |
O00421 Q4VBB0 O75307 Q96KP5 Q7KYQ9 B4DKQ8 Q6IPX0 Q9UPG0
|
| Accessions |
AAB57794 CAH60289 CAJ15094 CAJ15095 EAW64765 EAW64766 O00421 AF015524 AAC34601 AF015525 AAC34602 AJ344142 CAC82985 AK296673 BAG59270 AK313312 BAG36117 BC071682 AAH71682 BC096075 AAH96075 BC096076 AAH96076 DC387981 DQ892102 ABM83028 DQ895296 ABM86222 XM_011534208 XP_011532510 XM_011534209 XP_011532511 NM_001130910 NP_001124382 NM_003965 NP_003956
|
| Function |
Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:18397265, ECO:0000269|PubMed:20002784}; Multi-pass membrane protein {ECO:0000269|PubMed:18397265, ECO:0000269|PubMed:20002784}.
|
| Tissue Specificity |
Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T- cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B-cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients. {ECO:0000269|PubMed:11828366, ECO:0000269|PubMed:15188357, ECO:0000269|PubMed:18397265, ECO:0000269|PubMed:9473515}.
|