CCRL2

Gene Symbol	CCRL2
Entrez Gene	9034
Alt Symbol	ACKR5, CKRX, CRAM, CRAM-A, CRAM-B, HCR
Species	Human
Gene Type	protein-coding
Description	chemokine (C-C motif) receptor-like 2
Other Description	C-C chemokine receptor-like 2|atypical chemokine receptor 5|chemokine receptor CCR11|chemokine receptor X|putative MCP-1 chemokine receptor
Swissprots	O00421 Q4VBB0 O75307 Q96KP5 Q7KYQ9 B4DKQ8 Q6IPX0 Q9UPG0
Accessions	AAB57794 CAH60289 CAJ15094 CAJ15095 EAW64765 EAW64766 O00421 AF015524 AAC34601 AF015525 AAC34602 AJ344142 CAC82985 AK296673 BAG59270 AK313312 BAG36117 BC071682 AAH71682 BC096075 AAH96075 BC096076 AAH96076 DC387981 DQ892102 ABM83028 DQ895296 ABM86222 XM_011534208 XP_011532510 XM_011534209 XP_011532511 NM_001130910 NP_001124382 NM_003965 NP_003956
Function	Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:18397265, ECO:0000269|PubMed:20002784}; Multi-pass membrane protein {ECO:0000269|PubMed:18397265, ECO:0000269|PubMed:20002784}.
Tissue Specificity	Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T- cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B-cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients. {ECO:0000269|PubMed:11828366, ECO:0000269|PubMed:15188357, ECO:0000269|PubMed:18397265, ECO:0000269|PubMed:9473515}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CCRL2 full length protein - ab152942 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

CCRL2 Antibody Blocking Peptide - LS-E4246 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CCRL2 Antibody Blocking Peptide - LS-E25142 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CCRL2 Antibody Blocking Peptide - LS-E28131 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CCRL2 Antibody Blocking Peptide - LS-E28130 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human CCRL2/CRAM-A/B Protein - H00009034-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

CCRL2-Antibody-Center-Blocking-Peptide - BP16519c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CCRL2 Blocking Peptide - 33R-5410 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CCRL2 Blocking Peptide - abx063537 from Abbexa Category Peptide Species Human, Mouse, Rat

CCRL2 / CCR11 - H00009034-G01 from Acris Antibodies Category Protein Prices $440.00 Sizes 2 µg Species Human

CCRL2 / CCR11 - H00009034-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

CCRL2 fusion protein - ag4045 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CCRL2 Peptide - GWB-14AFCB from Genway Biotech Category Peptide Prices $196.00 Sizes 50 µg

CCRL2 Blocking Peptide - CBP2343 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

CCRL2 Peptide - BS5649P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

CCRL2/CRAM-A/B Recombinant Protein - H00009034-G01 from Novus Biologicals Category Protein Prices $449.00 Sizes 2 µg Species Human

C-C chemokine receptor-like 2 (CCRL2), Recombinant Protein - MBS1151454 from MyBioSource Category Protein Prices $1,375.00, $1,835.00 Sizes 1 mg (E-Coli), 1 mg (Yeast) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

CCRL2/CRAM-A/B Recombinant Protein Antigen - NBP1-85588PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CCRL2 Peptide, Human - M34GP02681H from Creative Peptides Category Peptide Source Synthetic. Species Human

C-C chemokine receptor-like 2 (CCRL2), Recombinant Protein - MBS7011083 from MyBioSource Category Protein Prices $1,155.00, $2,140.00, $3,345.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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