| Gene Symbol |
CHTOP
|
| Entrez Gene |
26097
|
| Alt Symbol |
C1orf77, FL-SRAG, FOP, SRAG, SRAG-3, SRAG-5, pp7704
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chromatin target of PRMT1
|
| Other Description |
chromatin target of PRMT1 protein|friend of PRMT1 protein|small protein rich in arginine and glycine
|
| Swissprots |
D3DV55 Q9H2L0 Q6NSM4 Q5T7Y9 Q9Y3Y2 Q8WYT9 Q9BUC5 Q0VAQ8 Q9H034 Q5T7Y8 Q5T7Z0 Q6PB28 Q2VPI9
|
| Accessions |
EAW53290 EAW53291 EAW53292 EAW53293 EAW53294 EAW53295 Q9Y3Y2 AF261137 AAG44673 AF318362 AAL55869 AI929184 AK095230 AK097870 AK308713 AK309844 AL050260 CAB43362 AL512704 CAC21650 BC002733 AAH02733 BC059949 AAH59949 BC070027 AAH70027 BC108721 AAI08722 BC120961 AAI20962 BC120962 AAI20963 BP375397 DC387712 XM_005245085 XP_005245142 XM_005245086 XP_005245143 NM_001206612 NP_001193541 NM_001244664 NP_001231593 NM_015607 NP_056422
|
| Function |
Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
|
| Subcellular Location |
Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm {ECO:0000250}. Nucleus speckle. Note=Mostly associated with facultative heterochromatin (By similarity). Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in an erythroid progenitor cell line derived from peripheral blood. {ECO:0000269|PubMed:20688955}.
|
![Western Blot: CHTOP Overexpression Lysate (Adult Normal) [NBL1-08330] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CHTOP.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7668_CHTOP%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08330-img0002.jpg)