| Gene Symbol |
SOSTDC1
|
| Entrez Gene |
25928
|
| Alt Symbol |
CDA019, ECTODIN, USAG1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sclerostin domain containing 1
|
| Other Description |
cystine-knot containing secreted protein|ectodermal BMP inhibitor|sclerostin domain-containing protein 1|uterine sensitization-associated protein-1
|
| Swissprots |
Q6X4U4 Q9Y3U3 Q96HJ7 A8MUA6
|
| Accessions |
AAQ96855 EAL24287 EAW93669 Q6X4U4 AB059270 BAC20331 AF361494 AAL57219 AI540640 AI927000 AK093408 BAG52710 AK315682 BAG38047 AL050024 CAB43243 AY255634 AAQ83296 BC008484 AAH08484 HQ448027 ADQ32508 NM_015464 NP_056279
|
| Function |
May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. {ECO:0000250, ECO:0000269|PubMed:15020244}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:15020244}.
|
| Tissue Specificity |
Highly expressed in kidney and weakly in lung. {ECO:0000269|PubMed:15020244}.
|