Gene Symbol | SOSTDC1 |
---|---|
Entrez Gene | 25928 |
Alt Symbol | CDA019, ECTODIN, USAG1 |
Species | Human |
Gene Type | protein-coding |
Description | sclerostin domain containing 1 |
Other Description | cystine-knot containing secreted protein|ectodermal BMP inhibitor|sclerostin domain-containing protein 1|uterine sensitization-associated protein-1 |
Swissprots | Q6X4U4 Q9Y3U3 Q96HJ7 A8MUA6 |
Accessions | AAQ96855 EAL24287 EAW93669 Q6X4U4 AB059270 BAC20331 AF361494 AAL57219 AI540640 AI927000 AK093408 BAG52710 AK315682 BAG38047 AL050024 CAB43243 AY255634 AAQ83296 BC008484 AAH08484 HQ448027 ADQ32508 NM_015464 NP_056279 |
Function | May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. {ECO:0000250, ECO:0000269|PubMed:15020244}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:15020244}. |
Tissue Specificity | Highly expressed in kidney and weakly in lung. {ECO:0000269|PubMed:15020244}. |