Gene Symbol | EIF3J |
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Entrez Gene | 8669 |
Alt Symbol | EIF3S1, eIF3-alpha, eIF3-p35 |
Species | Human |
Gene Type | protein-coding |
Description | eukaryotic translation initiation factor 3, subunit J |
Other Description | eukaryotic translation initiation factor 3 subunit J|eukaryotic translation initiation factor 3, subunit 1 (alpha, 35kD) |
Swissprots | Q9UI65 O75822 B4DUI3 Q9H8Q2 Q9BUD2 F5H425 |
Accessions | EAW77268 EAW77269 EAW77270 EAW77271 O75822 AF090923 AAF24039 AK002006 AK023388 BAB14555 AK300659 BAG62345 AL536561 BC002719 AAH02719 BU621047 CN414611 U97670 AAC78729 NM_001284335 NP_001271264 NM_001284336 NP_001271265 NM_003758 NP_003749 |
Function | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA. |
Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03009}. |
Top Pathways | RNA transport |
Human EIF3S1 protein fragment - ab113578 from Abcam
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EIF3J Antibody Blocking Peptide - LS-E23777 from LifeSpan Bioscience
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EIF3J Antibody Blocking Peptide - LS-E23776 from LifeSpan Bioscience
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EIF3J Partial Recombinant Protein - H00008669-Q01 from Novus Biologicals
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EIF3J Recombinant Protein - H00008669-P01 from Novus Biologicals
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Recombinant Human EIF3J Protein - NBP1-72511 from Novus Biologicals
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Human EIF3J protein - orb168283 from Biorbyt
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EIF3J protein (His tag) - 80R-2025 from Fitzgerald
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EIF3J / EIF3S1 (70-258, His-tag) - AR50097PU-N from Acris Antibodies
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EIF3J / EIF3S1 (70-258, His-tag) - AR50097PU-S from Acris Antibodies
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EIF3J / EIF3S1 - H00008669-P01-10 from Acris Antibodies
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EIF3J / EIF3S1 - H00008669-P01-25 from Acris Antibodies
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EIF3J / EIF3S1 - H00008669-Q01-10 from Acris Antibodies
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EIF3J / EIF3S1 - H00008669-Q01-25 from Acris Antibodies
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EIF3J, 70-258aa, Human, His tag, E.coli - 01-EIF3-J from ARP American Research Products
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EIF3J fusion protein - ag0678 from Proteintech Group
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Recombinant Human Eukaryotic EIF3J Protein - BP001960-PRO-970 from Syd Labs
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EIF3J, 70-258aa, Recombinant Protein - GWB-P0766L from Genway Biotech
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Recombinant Human EIF3J, GST-tagged - EIF3J-12371H from Creative Biomart
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Recombinant Human Eukaryotic Translation Initiation Factor 3, Subunit J, His-tagged - EIF3J-4733H from Creative Biomart
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EIF3J 70-258aa - CMB-1105 from Reagent Proteins
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Recombinant Human Eukaryotic translation initiation factor 3 subunit J(EIF3J) - CSB-YP007539HU CSB-EP007539HU CSB-BP007539HU CSB-MP007539HU from Cusabio
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EIF3J, 70-258aa, Human, His tag, E.coli - ATGP1272 from ATGen
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EIF3J Recombinant Protein Antigen - NBP2-13953PEP from Novus Biologicals
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EIF3J Blocking Peptide - abx061163 from Abbexa
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