EIF3J
| Gene Symbol | EIF3J |
|---|---|
| Entrez Gene | 8669 |
| Alt Symbol | EIF3S1, eIF3-alpha, eIF3-p35 |
| Species | Human |
| Gene Type | protein-coding |
| Description | eukaryotic translation initiation factor 3, subunit J |
| Other Description | eukaryotic translation initiation factor 3 subunit J|eukaryotic translation initiation factor 3, subunit 1 (alpha, 35kD) |
| Swissprots | Q9UI65 O75822 B4DUI3 Q9H8Q2 Q9BUD2 F5H425 |
| Accessions | EAW77268 EAW77269 EAW77270 EAW77271 O75822 AF090923 AAF24039 AK002006 AK023388 BAB14555 AK300659 BAG62345 AL536561 BC002719 AAH02719 BU621047 CN414611 U97670 AAC78729 NM_001284335 NP_001271264 NM_001284336 NP_001271265 NM_003758 NP_003749 |
| Function | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA. |
| Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03009}. |
| Top Pathways | RNA transport |
eIF3α CRISPR/Cas9 KO Plasmid (h) - sc-404354 from Santa Cruz Biotechnology
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eIF3α HDR Plasmid (h) - sc-404354-HDR from Santa Cruz Biotechnology
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eIF3α Double Nickase Plasmid (h) - sc-404354-NIC from Santa Cruz Biotechnology
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eIF3α Double Nickase Plasmid (h2) - sc-404354-NIC-2 from Santa Cruz Biotechnology
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eIF3α CRISPR Activation Plasmid (h) - sc-404354-ACT from Santa Cruz Biotechnology
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eIF3α CRISPR Activation Plasmid (h2) - sc-404354-ACT-2 from Santa Cruz Biotechnology
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eIF3α Lentiviral Activation Particles (h) - sc-404354-LAC from Santa Cruz Biotechnology
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eIF3α Lentiviral Activation Particles (h2) - sc-404354-LAC-2 from Santa Cruz Biotechnology
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eIF3α siRNA (h) - sc-40547 from Santa Cruz Biotechnology
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eIF3α shRNA Plasmid (h) - sc-40547-SH from Santa Cruz Biotechnology
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eIF3α shRNA (h) Lentiviral Particles - sc-40547-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU106071 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7767 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7767 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12726 from Sigma-Aldrich
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EIF3J siRNA (Human) - CRH5704 from Cohesion Biosciences
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EIF3J RNAi - H00008669-R01 from Novus Biologicals
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EIF3J - MBS8200475 from MyBioSource
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shRNA set against Human EIF3S1(NM_003758.2) - SHH029153 from Creative biogene
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EIF3J shRNA Plasmid (Human) - CHH5704 from Cohesion Biosciences
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EIF3J miRNA 3'UTR clone - MiUTR1H-03161 from Creative biogene
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