ADAM10

Gene Symbol	ADAM10
Entrez Gene	102
Alt Symbol	AD10, AD18, CD156c, HsT18717, MADM, RAK, kuz
Species	Human
Gene Type	protein-coding
Description	ADAM metallopeptidase domain 10
Other Description	CDw156|a disintegrin and metalloprotease domain 10|disintegrin and metalloproteinase domain-containing protein 10|kuzbanian protein homolog|mammalian disintegrin-metalloprotease
Swissprots	Q10742 B4DU28 Q92650 O14672
Accessions	CCQ43088 EAW77539 EAW77540 EAW77541 O14672 AA243020 AF009615 AAC51766 AK023460 AK300472 BAG62190 AY726599 BC055087 BC104659 BC126253 AAI26254 BC143935 BE327886 BE934813 BX372217 DA941750 Z48579 CAA88463 XM_005254117 XP_005254174 NM_001110 NP_001101
Function	Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth- like factor, ephrin-A2 and for constitutive and regulated alpha- secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Note=Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi.
Tissue Specificity	Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver. {ECO:0000269|PubMed:11511685, ECO:0000269|PubMed:9016778}.
Top Pathways	Alzheimer's disease, Epithelial cell signaling in Helicobacter pylori infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ADAM10 ELISA Kit (Sandwich ELISA) - LS-F4856 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 78.13 pg/ml Range 78.13-5000 pg/ml

Rat ADAM10 ELISA Kit (Sandwich ELISA) - LS-F6604 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 78 pg/ml Range 78.13-5000 pg/ml

Mouse ADAM10 ELISA Kit (Sandwich ELISA) - LS-F9938 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 9.38 pg/ml Range 78.13-5000 pg/ml

Human ADAM10 ELISA Kit - abx054469 from Abbexa Category ELISA Kit Sensitivity 0.8 pg/ml Range 2.8 pg/ml - 150 pg/ml

Human ADAM10 ELISA Kit - abx150542 from Abbexa Category ELISA Kit Sensitivity 24.6 pg/ml Range 62.5 pg/ml - 4000 pg/ml

A Disintegrin And Metalloprotease 10 (ADAM10), Human, ELISA Kit - SEA766Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 24.6pg/mL Range 62.5-4,000pg/mL

A Disintegrin And Metalloprotease 10, ADAM10, Human, ELISA Kit - E-EL-H0263 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 37.5 Range 62.5-4000pg/mL

Disintegrin and metalloproteinase domain-containing protein 10, ADAM10, Human, ELISA Kit - E0766h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

A Disintegrin And Metalloprotease 10, ADAM10, Rabbit, ELISA Kit - E-EL-RB1822 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

A Disintegrin And Metalloprotease 10, ADAM10, Chicken, ELISA Kit - E-EL-Ch0027 from ARP American Research Products Category ELISA Kit Prices $445.50 Sizes 96 t

A Disintegrin And Metalloprotease 10, ADAM10, Porcine, ELISA Kit - E-EL-P1949 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

A Disintegrin And Metalloprotease 10, ADAM10, Monkey, ELISA Kit - E-EL-MK1009 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human ADAM10 ELISA Kit - HA0734 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine ADAM10 ELISA Kit - AA0734 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

A Disintegrin And Metalloprotease 10, ELISA Kit - MBS737032 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

A Disintegrin and Metalloprotease 10, ELISA Kit - MBS009486 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

A Disintegrin and Metalloprotease 10, ELISA Kit - MBS059150 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

A Disintegrin and Metalloprotease 10, ELISA Kit - MBS076818 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 2.0pg/ml. Range 15.6pg/ml-500pg/ml.

A Disintegrin And Metalloprotease 10, ELISA Kit - MBS736290 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

A Disintegrin And Metalloprotease 10, ELISA Kit - MBS741939 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

A Disintegrin and Metalloprotease 10, ELISA Kit - MBS051768 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

A Disintegrin and Metalloprotease 10, ELISA Kit - MBS092732 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

A Disintegrin And Metalloprotease 10, ELISA Kit - MBS742462 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

A Disintegrin and Metalloprotease 10, ELISA Kit - MBS012867 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

A Disintegrin And Metalloprotease 10, ELISA Kit - MBS733773 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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