| Gene Symbol |
ADAM10
|
| Entrez Gene |
102
|
| Alt Symbol |
AD10, AD18, CD156c, HsT18717, MADM, RAK, kuz
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ADAM metallopeptidase domain 10
|
| Other Description |
CDw156|a disintegrin and metalloprotease domain 10|disintegrin and metalloproteinase domain-containing protein 10|kuzbanian protein homolog|mammalian disintegrin-metalloprotease
|
| Swissprots |
Q10742 B4DU28 Q92650 O14672
|
| Accessions |
CCQ43088 EAW77539 EAW77540 EAW77541 O14672 AA243020 AF009615 AAC51766 AK023460 AK300472 BAG62190 AY726599 BC055087 BC104659 BC126253 AAI26254 BC143935 BE327886 BE934813 BX372217 DA941750 Z48579 CAA88463 XM_005254117 XP_005254174 NM_001110 NP_001101
|
| Function |
Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth- like factor, ephrin-A2 and for constitutive and regulated alpha- secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Note=Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi.
|
| Tissue Specificity |
Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver. {ECO:0000269|PubMed:11511685, ECO:0000269|PubMed:9016778}.
|
| Top Pathways |
Alzheimer's disease, Epithelial cell signaling in Helicobacter pylori infection
|