SOCS3

Gene Symbol	SOCS3
Entrez Gene	395299
Alt Symbol	-
Species	Chicken
Gene Type	protein-coding
Description	suppressor of cytokine signaling 3
Other Description	SOCS-3|suppressors of cytokine signaling 3
Swissprots	Q90X67
Accessions	Q90X67 AF424806 AAL23933 EF554726 ABV03593 NM_204600 NP_989931
Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors (By similarity). Binding to JAK2 inhibits its kinase activity (By similarity). Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Regulates IL-6 signaling in vivo. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity). {ECO:0000250}.
Top Pathways	Ubiquitin mediated proteolysis, Jak-STAT signaling pathway, Insulin signaling pathway, Adipocytokine signaling pathway, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Suppressor of cytokine signaling 3, SOCS3, Chicken, ELISA Kit - E1684c from ARP American Research Products Category ELISA Kit Prices $796.00 Sizes 96 t Range 78-5000 pg/mL

Chicken SOCS3 ELISA Kit - CKS0144 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Chicken SOCS3 (Suppressors of Cytokine Signaling 3) ELISA Kit - E-EL-Ch0902 from Elabscience Category ELISA Kit Range ~

suppressor of cytokine signaling 3, ELISA Kit - MBS9322314 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Chicken Suppressors Of Cytokine Signaling 3 ELISA - E12S0137 from BlueGene Biotech Category ELISA Kit

Chicken SOCS3 (Suppressors of Cytokine Signaling 3) ELISA Kit - E-EL-Ch0902 from Iwai North America Inc. Category ELISA Kit Prices $722.50 Sizes 1 kit Sensitivity N/A

Chicken Suppressor of cytokine signaling 3 ELISA Kit - EKE55496 from Biomatik Category ELISA Kit Prices $875.60, $3,721.30, $7,004.80 Sizes 96 t, 5x96t, 10x96t Range 78-5000 pg/mL

Chicken SOCS3 ELISA Kit - E098374 from Biobool Category ELISA Kit

SOCS3 ELISA Kit (Chicken) (OKEH03978) - OKEH03978 from Aviva Systems Biology Category ELISA Kit Prices $515.00 Sizes 96 wells Sensitivity < 39 pg/mL Range 78 - 5,000 pg/mL

Chicken SOCS3 ELISA Kit - ECKS0144 from ABclonal Category ELISA Kit Prices $495.00 Sizes 96 t

Chicken Suppressor of cytokine signaling 3 ELISA Kit - EK3871 from Signalway Antibody Category ELISA Kit Prices $799.00 Sizes 1x96t Range 0.312-20 nmol/mL

Suppressor of cytokine signaling 3, ELISA Kit - MBS289774 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 78-5000 pg/mL

Suppressor of cytokine signaling 3, ELISA Kit - MBS9427701 from MyBioSource Category ELISA Kit Prices $720.00 Sizes 96 tests Range 78-5000 pg/mL

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