| Gene Symbol |
SOCS3
|
| Entrez Gene |
395299
|
| Alt Symbol |
-
|
| Species |
Chicken
|
| Gene Type |
protein-coding
|
| Description |
suppressor of cytokine signaling 3
|
| Other Description |
SOCS-3|suppressors of cytokine signaling 3
|
| Swissprots |
Q90X67
|
| Accessions |
Q90X67 AF424806 AAL23933 EF554726 ABV03593 NM_204600 NP_989931
|
| Function |
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors (By similarity). Binding to JAK2 inhibits its kinase activity (By similarity). Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Regulates IL-6 signaling in vivo. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity). {ECO:0000250}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Jak-STAT signaling pathway, Insulin signaling pathway, Adipocytokine signaling pathway, Influenza A
|