SOCS3

Gene Symbol SOCS3
Entrez Gene 395299
Alt Symbol -
Species Chicken
Gene Type protein-coding
Description suppressor of cytokine signaling 3
Other Description SOCS-3|suppressors of cytokine signaling 3
Swissprots Q90X67
Accessions Q90X67 AF424806 AAL23933 EF554726 ABV03593 NM_204600 NP_989931
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors (By similarity). Binding to JAK2 inhibits its kinase activity (By similarity). Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Regulates IL-6 signaling in vivo. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity). {ECO:0000250}.
Top Pathways Ubiquitin mediated proteolysis, Jak-STAT signaling pathway, Insulin signaling pathway, Adipocytokine signaling pathway, Influenza A

Recombinant Chicken SOCS3 - SOCS3-6168C from Creative Biomart

Category Protein
Source Mammalian Cells
Species Chicken

Recombinant Chicken Suppressor of cytokine signaling 3(SOCS3) - CSB-YP022392CH CSB-EP022392CH CSB-BP022392CH CSB-MP022392CH from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Chicken

Suppressor of cytokine signaling 3 (SOCS3), Recombinant Protein - MBS1394767 from MyBioSource

Category Protein
Prices $960.00, $960.00, $1,185.00, $1,185.00, $1,425.00, $1,425.00, $1,885.00, $1,885.00, $1,885.00, $2,805.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Chicken
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