| Gene Symbol |
TPPP
|
| Entrez Gene |
11076
|
| Alt Symbol |
TPPP/p25, TPPP1, p24, p25, p25alpha
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tubulin polymerization promoting protein
|
| Other Description |
25 kDa brain-specific protein|brain specific protein p25 alpha|glycogen synthase kinase 3 (GSK3) inhibitor p24|p25-alpha|tubulin polymerization-promoting protein
|
| Swissprots |
O94811
|
| Accessions |
EAW51015 EAW51016 O94811 AB017016 BAA36164 AI796918 AK054920 BAG51443 AK098392 AW955330 AY319261 AAQ96657 BC040496 AAH40496 BC131506 AAI31507 BC152382 AAI52383 BQ066916 BT020035 AAV38838 BU726600 DB478250 DB546894 XM_005248237 XP_005248294 NM_007030 NP_008961
|
| Function |
May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown. {ECO:0000269|PubMed:17105200, ECO:0000269|PubMed:17693641, ECO:0000269|PubMed:18028908}.
|
| Subcellular Location |
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:10083737}.
|