ITGB4
| Gene Symbol | ITGB4 |
|---|---|
| Entrez Gene | 3691 |
| Alt Symbol | CD104 |
| Species | Human |
| Gene Type | protein-coding |
| Description | integrin, beta 4 |
| Other Description | CD104 antigen|GP150|integrin beta-4|integrin beta-4 subunit |
| Swissprots | O15339 O14691 A0AVL6 Q0VF97 O15341 O15340 P16144 Q9UIQ4 O14690 |
| Accessions | AAB65422 AAC51632 AAC51633 AAC51634 CAB61345 EAW89305 EAW89306 EAW89307 EAW89308 EAW89309 EAW89310 EAW89311 EAW89312 EAW89313 EAW89314 EAW89315 P16144 AB208913 BAD92150 AF011375 AAB65421 AI318403 AK304792 BAG65542 AK310952 BC109238 AAI09239 BC118916 AAI18917 BC126411 AAI26412 BC143738 AAI43739 BC143742 AAI43743 CA391583 X51841 CAA36134 X52186 CAA36433 X53587 CAA37656 XM_005257309 XP_005257366 XM_005257311 XP_005257368 XM_005257312 XP_005257369 XM_006721866 XP_006721929 XM_006721867 XP_006721930 XM_006721868 XP_006721931 XM_006721870 XP_006721933 XM_011524751 XP_011523053 XM_011524752 XP_011523054 NM_000213 NP_000204 NM_001005619 NP_001005619 NM_001005731 NP_001005731 |
| Function | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Note=Colocalizes with DST at the leading edge of migrating keratinocytes. |
| Tissue Specificity | Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach. |
| Top Pathways | Focal adhesion, ECM-receptor interaction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy |
Active human Integrin beta 4 (phospho Y1494) peptide - ab42718 from Abcam
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Human Integrin beta 4 (phospho Y1526) peptide - ab42719 from Abcam
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Human Integrin beta 4 protein fragment - ab152480 from Abcam
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Recombinant Human Integrin beta 4/CD104 Protein - H00003691-Q01 from Novus Biologicals
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CD104 Blocking Peptide - abx062813 from Abbexa
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Human Integrin Beta 4 Protein - abx067295 from Abbexa
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CD104 / Integrin beta-4 - H00003691-Q01-10 from Acris Antibodies
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CD104 / Integrin beta-4 - H00003691-Q01-25 from Acris Antibodies
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Integrin Beta 4 (ITGb4), Human - 20-7716 from ARP American Research Products
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Integrin beta-4 fusion protein - Ag17395 from Proteintech Group
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Integrin beta-4 fusion protein - ag16450 from Proteintech Group
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ITGB4 fusion protein - ag17396 from Proteintech Group
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ITGB4 fusion protein - ag16460 from Proteintech Group
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Recombinant Human ITGB4, GST-tagged - ITGB4-181H from Creative Biomart
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Recombinant Integrin Beta 4 (ITGb4) - RPB440Hu01 from Uscn Life Science Inc.
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Recombinant Integrin Beta 4 (ITGb4) - RPB440Mu01 from Uscn Life Science Inc.
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CD104 Blocking Peptide - CBP1619 from Cohesion Biosciences
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Integrin β4 (L1506) Peptide - BS1802P from Bioworld Technology
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Recombinant Integrin Beta 4 (ITGb4) - RPB440Hu01 from Cloud-clone
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Recombinant Human Integrin beta-4(ITGB4) - CSB-YP011887HU CSB-EP011887HU CSB-BP011887HU CSB-MP011887HU from Cusabio
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CD104 / Integrin beta-4 (transcript variant 1) - TP320541 from Acris Antibodies
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Integrin beta 4/CD104 Recombinant Protein Antigen - NBP2-38298PEP from Novus Biologicals
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Integrin beta 4/CD104 Recombinant Protein Antigen - NBP2-38297PEP from Novus Biologicals
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CD104 (pY1510) Blocking Peptide - abx061143 from Abbexa
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ITGB4 Peptide, Human - M34GP07807H from Creative Peptides
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