ITGB4

Gene Symbol ITGB4
Entrez Gene 3691
Alt Symbol CD104
Species Human
Gene Type protein-coding
Description integrin, beta 4
Other Description CD104 antigen|GP150|integrin beta-4|integrin beta-4 subunit
Swissprots O15339 O14691 A0AVL6 Q0VF97 O15341 O15340 P16144 Q9UIQ4 O14690
Accessions AAB65422 AAC51632 AAC51633 AAC51634 CAB61345 EAW89305 EAW89306 EAW89307 EAW89308 EAW89309 EAW89310 EAW89311 EAW89312 EAW89313 EAW89314 EAW89315 P16144 AB208913 BAD92150 AF011375 AAB65421 AI318403 AK304792 BAG65542 AK310952 BC109238 AAI09239 BC118916 AAI18917 BC126411 AAI26412 BC143738 AAI43739 BC143742 AAI43743 CA391583 X51841 CAA36134 X52186 CAA36433 X53587 CAA37656 XM_005257309 XP_005257366 XM_005257311 XP_005257368 XM_005257312 XP_005257369 XM_006721866 XP_006721929 XM_006721867 XP_006721930 XM_006721868 XP_006721931 XM_006721870 XP_006721933 XM_011524751 XP_011523053 XM_011524752 XP_011523054 NM_000213 NP_000204 NM_001005619 NP_001005619 NM_001005731 NP_001005731
Function Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.
Subcellular Location Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Note=Colocalizes with DST at the leading edge of migrating keratinocytes.
Tissue Specificity Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.
Top Pathways Focal adhesion, ECM-receptor interaction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy

Integrin β4 (D8P6C) XP ® Rabbit mAb - 14803 from Cell Signaling Technology

Prices $109.00, $282.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D8P6C
Western blot analysis of extracts from HT-29, LNCaP, and A-204 cells using Integrin β4 (D8P6C) XP ® Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

Integrin β4 Antibody - 4707 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell types using Integrin β4 Antibody.

Integrin β4 (H-101) - sc-9090 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Integrin β4 (H-101): sc-9090. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing membrane staining of trophoblastic cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Integrin β4 (C-20) - sc-6628 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Integrin β4 (C-20): sc-6628. Western blot analysis of Integrin β4 expression in SW480 whole cell lysate.

Integrin β4 (G-7) - sc-13127 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin β4 (G-7): sc-13127. Western blot analysis of Integrin β4 expression in SW480 whole cell lysate.

Integrin β4 (N-20) - sc-6629 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Integrin β4 (N-20): sc-6629. Western blot analysis of Integrin β4 expression in SW480 whole cell lysate.

Integrin β4 (H-1) - sc-55514 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin β4 (H-1): sc-55514. Western blot analysis of Integrin β4 expression in pervanadate treated A-431 whole cell lysate.

Integrin β4 (A9) - sc-13543 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin β4 (A9) PE: sc-13545 PE. FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG<sub>2a</sub>: sc-2866.

Integrin β4 (7) - sc-135950 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Integrin β4 (7): sc-135950. Western blot analysis of Integrin β4 expression in A-431 whole cell lysate.

Anti-Integrin beta 4 (phospho Y1494) antibody - ab29043 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Integrin beta 4 (phospho Y1494) antibody (ab29043)Lane 1 : A431 (25 µg/lane) serum starved overnightLane 2 : A431 (25 µg/lane) serum treated with pervanadate (1 mM) for 30 min with absence of peptideLane 3 : A431 (25 µg/lane) serum treated with pervanadate (1 mM) for 30 min with presence of phospho-integrin-beta4 (Tyr-1494) peptideLane 4 : A431 (25 µg/lane) serum treated with pervanadate (1 mM) for 30 min with presence of phospho-integrin-beta4 (Tyr-1526) peptide

Anti-Integrin beta 4 (phospho Y1510) antibody - ab192805 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed paraffin embedded human breast carcinoma tissue labeling Integrin beta 4 (phospho Y1510) with ab192805 at 1/50 dilution (left) and blocking peptide (right)

Anti-Integrin beta 4 (phospho Y1510) antibody - ab63546 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab63546 at 1/50 dilution staining human breast carcinoma tissue, without (left) and with (right) immunizing peptide; paraffin embedded.

Anti-Integrin beta 4 (phospho Y1526) antibody - ab29044 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Integrin beta 4 (phospho Y1526) antibody (ab29044)Lane 1 : A431 cell lysate, starvedLane 2 : A431 cell lysate, treated with pervanadate for 30 minThe top band in each lane is 200 kDa.

Anti-Integrin beta 4 antibody - ab112066 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Integrin beta 4 antibody (ab112066) at 1 µg/ml + Small Intestine (Human) Tissue Lysate - adult normal tissue (ab29276) at 25 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Integrin beta 4 antibody - ab63438 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab63438 at 1/50 - 1/100 dilution staining Integrin beta 4 in human breast carcinoma by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.

Anti-Integrin beta 4 antibody [439-9B] - ab110167 from Abcam

Prices $384.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 439-9B
ab110167 at 20 µg/ml staining integrin beta 4 in Formalin-Fixed, Paraffin-Embedded Human Pancreas(ab29816). Sections were incubated with a biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Anti-Integrin beta 4 antibody [439-9B] - ab95583 from Abcam

Prices $376.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 439-9B
ab95583 using 0.5µg staining Integrin beta 4 in A549 cells by Flow Cytometry (shown in purple histogram). Staining with Rat IgG2b ? Isotype Control FITC shown in Blue histogram. Followed by Anti-Rat IgG Biotin and Streptavidin PE.

Anti-Integrin beta 4 antibody [439-9B] (Biotin) - ab95584 from Abcam

Prices $189.00
Sizes 50 µg
Host Rat
Clonality Monoclonal
Clone 439-9B
Staining of the A549 cell line with 0.125 µg of Rat IgG2b ? Isotype Control Biotin (open histogram) or 0.125 µg of ab95584 (filled histogram) followed by Streptavidin PE. Total viable cells were used for analysis.

Anti-Integrin beta 4 antibody [450-9D] (FITC) - ab22486 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 450-9D

Anti-Integrin beta 4 antibody [58XB4] - ab128068 from Abcam

Prices $379.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone 58XB4
Immunohistochemistry on frozen section of human skin showing strong staining of basal membrane (e.g. cells of sebaceous gland and sweat gland and cells forming the hair in the hair shaft) and connective tissue; no staining of muscle cells

Anti-Integrin beta 4 antibody [EPR17517] - ab182120 from Abcam

Prices $347.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR17517
Immunohistochemical analysis of paraffin-embedded Human cervical carcinoma tissue labeling Integrin beta 4 with ab182120 at 1/250 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP) (ab97051) secondary antibody at 1/500 dilution. Membrane and cytoplasm staining on Human cervical carcinoma is observed. Counter stained with Hematoxylin.Secondary antibody only control: Used PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/500 dilution.

Anti-Integrin beta 4 antibody [EPR8558(2)] - ab168386 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8558(2)
ab168386 showing +ve staining in Human normal spleen.

Anti-Integrin beta 4 antibody [EPR8559] - ab133682 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8559
All lanes : Anti-Integrin beta 4 antibody [EPR8559] (ab133682) at 1/1000 dilutionLane 1 : BxPC-3 cell lysateLane 2 : SW480 cell lysateLysates/proteins at 10 µg/ml per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Integrin beta 4 antibody [M126] - ab29042 from Abcam

Prices $398.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone M126
Immunofluorescence analysis of rat 804G cells, staining Integrin beta 4 with ab29042.Cells were fixed in 4% formaldehyde in PBS for 8 minutes, washed thoroughly in PBS, and permeabilized in 0.1% Triton X-100 in PBS for 10 minutes. Samples were incubated with primary antibody at 37°C for 1 hour. The cells on coverslips were washed with PBS, and AlexaFluor®597-conjugated secondary antibodies were applied for 1 hour at 37°C.

Anti-Integrin beta 4 antibody [UMA9] - ab197772 from Abcam

Prices $359.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone UMA9
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