| Gene Symbol |
CCL14
|
| Entrez Gene |
6358
|
| Alt Symbol |
CC-1, CC-3, CKB1, HCC-1, HCC-1(1-74), HCC-1/HCC-3, HCC-3, MCIF, NCC-2, NCC2, SCYA14, SCYL2, SY14
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chemokine (C-C motif) ligand 14
|
| Other Description |
C-C motif chemokine 14|chemokine CC-1/CC-3|chemokine CC-3|hemofiltrate CC chemokine 1|new CC chemokine 2|small inducible cytokine subfamily A (Cys-Cys), member 14|small-inducible cytokine A14
|
| Swissprots |
Q16627 E1P649 Q13954 E1P650
|
| Accessions |
AAC63329 AAF23982 CAA89263 EAW80105 EAW80106 EAW80107 EAW80108 Q16627 AA612866 AK122606 BC038289 AAH38289 BC045165 AAH45165 BC050647 BI496964 BM853193 DA821276 HQ257907 ADR82662 Z49270 CAA89264 NM_032962 NP_116738 NM_032963 NP_116739 NM_004166
|
| Function |
Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5. {ECO:0000269|PubMed:11085751}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma. {ECO:0000269|PubMed:9600961}.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Chemokine signaling pathway
|
![Western Blot: CCL14 Overexpression Lysate (Adult Normal) [NBL1-08844] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CCL14.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9590_CCL14%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08844-img0002.jpg)