CCL14
| Gene Symbol | CCL14 |
|---|---|
| Entrez Gene | 6358 |
| Alt Symbol | CC-1, CC-3, CKB1, HCC-1, HCC-1(1-74), HCC-1/HCC-3, HCC-3, MCIF, NCC-2, NCC2, SCYA14, SCYL2, SY14 |
| Species | Human |
| Gene Type | protein-coding |
| Description | chemokine (C-C motif) ligand 14 |
| Other Description | C-C motif chemokine 14|chemokine CC-1/CC-3|chemokine CC-3|hemofiltrate CC chemokine 1|new CC chemokine 2|small inducible cytokine subfamily A (Cys-Cys), member 14|small-inducible cytokine A14 |
| Swissprots | Q16627 E1P649 Q13954 E1P650 |
| Accessions | AAC63329 AAF23982 CAA89263 EAW80105 EAW80106 EAW80107 EAW80108 Q16627 AA612866 AK122606 BC038289 AAH38289 BC045165 AAH45165 BC050647 BI496964 BM853193 DA821276 HQ257907 ADR82662 Z49270 CAA89264 NM_032962 NP_116738 NM_032963 NP_116739 NM_004166 |
| Function | Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5. {ECO:0000269|PubMed:11085751}. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma. {ECO:0000269|PubMed:9600961}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway |
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