PARK7

Gene Symbol	PARK7
Entrez Gene	11315
Alt Symbol	DJ-1, DJ1, HEL-S-67p
Species	Human
Gene Type	protein-coding
Description	parkinson protein 7
Other Description	Parkinson disease (autosomal recessive, early onset) 7|epididymis secretory sperm binding protein Li 67p|oncogene DJ1|protein DJ-1|protein deglycase DJ-1
Swissprots	Q7LFU2 B2R4Z1 Q99497 Q6DR95 O14805
Accessions	AAT68961 EAW71591 Q99497 AB073864 BAB71782 AF021819 AAC12806 AK091679 AK130886 AK312000 BAG34938 BC008188 AAH08188 BP248330 D61380 BAA09603 EU794641 ACJ13695 HQ447919 ADQ32403 XM_005263424 XP_005263481 NM_001123377 NP_001116849 NM_007262 NP_009193
Function	Protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteines, arginines and lysines residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) (PubMed:25416785). Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function (PubMed:17015834, PubMed:20304780, PubMed:18711745, PubMed:12796482, PubMed:19229105, PubMed:25416785). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for
Subcellular Location	Cell membrane {ECO:0000250|UniProtKB:O88767}; Lipid-anchor {ECO:0000250|UniProtKB:O88767}. Cytoplasm {ECO:0000269|PubMed:12851414, ECO:0000269|PubMed:14579415, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:19229105}. Nucleus {ECO:0000269|PubMed:12851414, ECO:0000269|PubMed:14579415, ECO:0000269|PubMed:15976810}. Membrane raft {ECO:0000250|UniProtKB:O88767}. Mitochondrion {ECO:0000269|PubMed:15181200, ECO:0000269|PubMed:18711745, ECO:0000269|PubMed:19229105}. Note=Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage (PubMed:18711745). Detected in tau inclusions in brains from neurodegenerative disease patients (PubMed:14705119). Membrane raft localization in astrocytes and neuronal cells requires palmitoylation. {ECO:0000269|PubMed:14705119, ECO:0000
Tissue Specificity	Highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart. Detected at slightly lower levels in placenta and brain (at protein level). Detected in astrocytes, Sertoli cells, spermatogonia, spermatids and spermatozoa. {ECO:0000269|PubMed:14579415, ECO:0000269|PubMed:14662519, ECO:0000269|PubMed:14705119, ECO:0000269|PubMed:9070310}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human PARK7 / DJ-1 ELISA Kit (Cell-Based ELISA) - LS-F1943 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 15.63-1000 pg/ml

Human PARK7 / DJ-1 ELISA Kit (Sandwich ELISA) - LS-F9726 from LifeSpan Bioscience Category ELISA Kit Prices $790.00 Sizes 1 plate Sensitivity 6.3 pg/ml Range 15.63-1000 pg/ml

Human Park7/DJ-1 DuoSet ELISA - DY3995 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 62.50 - 4,000 pg/mL

Mouse Park7/DJ-1 DuoSet ELISA - DY8136-05 from R&D Systems Category ELISA Kit Prices $299.00 Sizes 1 kit (for 5 Plates) Range 0.313 - 20 ng/mL

Human PARK7 ELISA Kit - abx152648 from Abbexa Category ELISA Kit Sensitivity 0.64 ng/ml Range 1.563 ng/ml - 100 ng/ml

Parkinson Disease Protein 7 (PARK7), Human, ELISA Kit - SEL059Hu from ARP American Research Products Category ELISA Kit Prices $790.00 Sizes 96 t Sensitivity 0.64ng/mL Range 1.563-100ng/mL

Protein DJ-1 (PARK7), Human, ELISA Kit - CSB-E12024h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.058 ng/ml Range 0.235 ng/ml-15 ng/ml

DJ-1 Colorimetric Cell-Based ELISA Kit - CB5206 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

PARK7 (Human) ELISA Kit - DEIA4026 from Creative Diagnostics Category ELISA Kit Sensitivity The mean minimum detectable dose was 0.545 ng/mL. Range Dilution factors need to be taken into consideration in calculating the DJ-1/PARK7 concentration. Results exceeding DJ-1/PARK7 level of 1000 ng/mL should be repeated with diluted samples.

ELISA Kit for Parkinson Disease Protein 7 (PARK7) - SEL059Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 6.3pg/mL. Range 15.63-1000pg/mL The standard curve concentrations used for the ELISA’s were 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL, 15.63pg/mL

Human Protein DJ-1 (PARK7) ELISA kit - CSB-E12024h from Cusabio Category ELISA Kit Sensitivity 0.058ng/ml Range 0.235 ng/ml-15 ng/ml

ELISA Kit for Parkinson Disease Protein 7 (PARK7) - SEL059Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 6.3pg/mL. Range 15.625-1000pg/mL The standard curve concentrations used for the ELISA's were 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL, 15.625pg/mL

Parkinson disease (autosomal recessive, early onset) 7, ELISA Kit - MBS702647 from MyBioSource Category ELISA Kit Prices $250.00, $550.00, $795.00, $2,890.00, $5,465.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human PARK7 is typically less than 0.058 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 0.235 ng/ml -15 ng/ml.

Custom Human Park7 ELISA - ELH-PARK7 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human Park7/DJ-1 ELISA Development Kit - DEIABL25 from Creative Diagnostics Category ELISA Kit

DJ-1 ELISA Kit - DEIA-XYA935 from Creative Diagnostics Category ELISA Kit

Human PARK7 ELISA Kit - abx574047 from Abbexa Category ELISA Kit Sensitivity 0.64 ng/ml Range 1.563 ng/ml - 100 ng/ml

Human Park7 ELISA - RAB1625 from Sigma-Aldrich Prices $615.00 Sizes 1 kt

Human Protein DJ-1 (PARK7) ELISA Kit - EKC35193 from Biomatik Category ELISA Kit Prices $795.00, $3,021.00, $5,645.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.058 ng/ml Range 0.235 ng/ml-15 ng/ml

Human Park7/DJ-1 ELISA Kit - NR-E10338 from Novatein Biosciences Category ELISA Kit Prices $532.50, $1,049.50, $1,878.90 Sizes 1x96t, 2x96t, 4x96t Range 62.5-4000pg/ml

Human Park7/DJ-1 ELISA - ELH-PARK7-1 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human PARK7 ELISA Kit - E028334 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human PARK7 is typically less than 0.058 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the m

PARK7 ELISA Kit (Human) (OKCD00717) - OKCD00717 from Aviva Systems Biology Category ELISA Kit Prices $585.00 Sizes 96 wells Sensitivity < 0.60 ng/mL Range 1.56-100 ng/mL

PARK7 High Sensitivity ELISA Kit (Human) (OKCD01385) - OKCD01385 from Aviva Systems Biology Category ELISA Kit Prices $635.00 Sizes 96 wells Sensitivity 26.3 pg/mL Range 62.5-1,000 pg/mL

anti-PARK7 / DJ-1 antibody [4H4] - ARG52388 from Arigo Biolaboratories Category ELISA Kit

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