PARK7

Gene Symbol	PARK7
Entrez Gene	11315
Alt Symbol	DJ-1, DJ1, HEL-S-67p
Species	Human
Gene Type	protein-coding
Description	parkinson protein 7
Other Description	Parkinson disease (autosomal recessive, early onset) 7|epididymis secretory sperm binding protein Li 67p|oncogene DJ1|protein DJ-1|protein deglycase DJ-1
Swissprots	Q7LFU2 B2R4Z1 Q99497 Q6DR95 O14805
Accessions	AAT68961 EAW71591 Q99497 AB073864 BAB71782 AF021819 AAC12806 AK091679 AK130886 AK312000 BAG34938 BC008188 AAH08188 BP248330 D61380 BAA09603 EU794641 ACJ13695 HQ447919 ADQ32403 XM_005263424 XP_005263481 NM_001123377 NP_001116849 NM_007262 NP_009193
Function	Protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteines, arginines and lysines residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) (PubMed:25416785). Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function (PubMed:17015834, PubMed:20304780, PubMed:18711745, PubMed:12796482, PubMed:19229105, PubMed:25416785). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for
Subcellular Location	Cell membrane {ECO:0000250|UniProtKB:O88767}; Lipid-anchor {ECO:0000250|UniProtKB:O88767}. Cytoplasm {ECO:0000269|PubMed:12851414, ECO:0000269|PubMed:14579415, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:19229105}. Nucleus {ECO:0000269|PubMed:12851414, ECO:0000269|PubMed:14579415, ECO:0000269|PubMed:15976810}. Membrane raft {ECO:0000250|UniProtKB:O88767}. Mitochondrion {ECO:0000269|PubMed:15181200, ECO:0000269|PubMed:18711745, ECO:0000269|PubMed:19229105}. Note=Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage (PubMed:18711745). Detected in tau inclusions in brains from neurodegenerative disease patients (PubMed:14705119). Membrane raft localization in astrocytes and neuronal cells requires palmitoylation. {ECO:0000269|PubMed:14705119, ECO:0000
Tissue Specificity	Highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart. Detected at slightly lower levels in placenta and brain (at protein level). Detected in astrocytes, Sertoli cells, spermatogonia, spermatids and spermatozoa. {ECO:0000269|PubMed:14579415, ECO:0000269|PubMed:14662519, ECO:0000269|PubMed:14705119, ECO:0000269|PubMed:9070310}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PARK7/DJ1 full length protein - ab51198 from Abcam Category Protein Source E. coli Species Human

Human PARK7/DJ1 full length protein - ab124312 from Abcam Category Protein Source E. coli Species Human

Human PARK7/DJ1 peptide - ab18659 from Abcam Category Peptide

Human PARK7/DJ1 peptide - ab22993 from Abcam Category Peptide Species Human

Human PARK7/DJ1 protein fragment - ab140590 from Abcam Category Protein Source E. coli Species Human

PARK7 / DJ-1 Antibody Blocking Peptide - LS-E25510 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PARK7 / DJ-1 Antibody Blocking Peptide - LS-E8227 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PARK7 / DJ-1 Antibody Blocking Peptide - LS-E18457 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Park7/DJ-1 Recombinant Protein - H00011315-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Park7/DJ-1 Partial Recombinant Protein - H00011315-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Park7/DJ-1 Protein - NBC1-18334 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E. coli Species Human

Park7/DJ-1 Peptide - P2049 from Novus Biologicals Category Peptide Species Human

DJ-1-Antibody-N-term-Blocking-peptide - BP6407a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Park7 / DJ-1 blocking peptide - GTX89847-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

Recombinant human protein DJ-1 (OPCA00520) - OPCA00520 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

PARK7 Protein (OPPA01449) - OPPA01449 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human Parkinson Disease Protein 7 protein - orb81255 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

Human PARK7 protein - orb245186 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

DJ1 protein - 30R-3123 from Fitzgerald Category Protein Prices $210.00 Sizes 50 µg Source E.coli

PARK7 Blocking Peptide - 33R-9402 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PARK7 protein (His tag) - 80R-1015 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

DJ-1 Blocking Peptide - abx063740 from Abbexa Category Peptide Species Human, Bovine, Pig

DJ-1 Blocking Peptide - abx063741 from Abbexa Category Peptide Species Human, Rat, Monkey

Human PARK7 Protein - abx060008 from Abbexa Category Protein Source Yeast Species Human

Human PARK7 Protein - abx068435 from Abbexa Category Protein Source E.coli Species Human

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