Chil1

Gene Symbol Chil1
Entrez Gene 12654
Alt Symbol AW208766, Brp39, Chi3l1, Gp39
Species Mouse
Gene Type protein-coding
Description chitinase-like 1
Other Description CGP-39|GP-39|breast regression protein 39|cartilage glycoprotein 39|chitinase 3-like 1|chitinase-3-like protein 1
Swissprots Q61362 B0FEU7 Q8BKL8 D3Z2P2 Q99J84 Q3U291 Q4FJW9
Accessions EDL39625 EDL39626 Q61362 AI853039 AK051475 BAC34654 AK155412 BAE33251 BC003780 AAH03780 BC004734 AAH04734 BC005611 AAH05611 CJ147225 CT010283 CAJ18491 EU313768 ABY53363 X93035 CAA63603 XM_006529111 XP_006529174 XM_006529112 XP_006529175 NM_007695 NP_031721
Function Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. {ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:19041398, ECO:0000269|PubMed:19414556, ECO:0000269|PubMed:20558631, ECO:00
Subcellular Location Secreted, extracellular space. Cytoplasm. Endoplasmic reticulum. Note=Detected in bronchoalveolar lavage (BAL) fluids. Localizes mainly to endoplasmic reticulum when overexpressed in cells, with some protein also detected throughout the cytoplasm.
Tissue Specificity Detected in lung in pulmonary macrophages and alveolar type 2 cells and in bronchoalveolar lavage (BAL) fluids. Expressed in mammary tumor cells (at protein level). Expressed in lung. Not detected in non-inflammatory colon. {ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:19414556, ECO:0000269|PubMed:20558631, ECO:0000269|PubMed:21866546}.

GP-39 (D-6) - sc-376941 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GP-39 (D-6): sc-376941. Western blot analysis of GP-39 expression in non-transfected: sc-117752 (A) and mouse GP-39 transfected: sc-120569 (B) 293T whole cell lysates.

GP-39 (E-11) - sc-376910 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GP-39 (E-11): sc-376910. Western blot analysis of GP-39 expression in non-transfected: sc-117752 (A) and mouse GP-39 transfected: sc-120569 (B) 293T whole cell lysates.

GP-39 (M-43) - sc-98954 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
GP-39 (M-43): sc-98954. Western blot analysis of GP-39 expression in non-transfected: sc-117752 (A) and mouse GP-39 transfected: sc-120569 (B) 293T whole cell lysates.

GP-39 (E-15) - sc-30859 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GP-39 (M-20) - sc-30861 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GP-39 (M-20): sc-30861. Western blot analysis of GP-39 expression in postnatal mouse liver tissue extract.

Chitinase 3-like 1 Antibody (321924) [Unconjugated] - MAB2649 from Novus Biologicals

Prices $99.00, $259.00
Sizes 25 µg, 100 µg
Host Rat
Clonality Monoclonal
Clone 321924
Western blot shows lysates of mouse lung tissue and mouse liver tissue. PVDF membrane was probed with 1 µg/mL of Rat Anti-Mouse Chitinase 3‑like 1 Monoclonal Antibody (Catalog # MAB2649) followed by HRP-conjugated Anti-Rat IgG Secondary Antibody (Catalog # HAF005). A specific band was detected for Chitinase 3‑like 1 at approximately 40 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Chitinase 3-like 1 Antibody - AF2649 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Chitinase 3-like 1 Antibody [Biotin] - BAF2649 from Novus Biologicals

Prices $390.00
Sizes 50 µg
Host Sheep
Clonality Polyclonal

Anti-Glycoprotein 39, Cartilage (GP39) - 20-3830 from ARP American Research Products

Prices $329.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

CHI3L1 Antibody - TGB-976 from Reagent Proteins

Prices $348.00, $675.00
Sizes 20.00 µg, 100.00 µg
Host Mouse
Clonality Monoclonal

Polyclonal Antibody to Glycoprotein 39, Cartilage (GP39) - PAB463Mu01 from Cloud-clone

Host Rabbit
Clonality Polyclonal

CHI3L1 / YKL40 Antibody, Rabbit PAb, Antigen Affinity Purified - 50929-T32-50 from Sino Biological

Prices $99.00, $99.00, $99.00
Sizes 50 µg, 100 µg, 200 µg
Host Rabbit
Clonality Polyclonal

CHI3L1 antibody - orb362459 from Biorbyt

Prices $323.00, $442.00, $570.00
Sizes 50 μg, 100 μg, 200 μg
Host Rabbit
Clonality Polyclonal
Clone $335

Anti-CHI3L1 Picoband™ Antibody A01283-1 - A01283-1 from Boster Bio

Prices $240.00
Sizes 1
Host Rabbit
Clonality Polyclonal

Chi3l1 Antibody / Chitinase-3-like protein 1 (R32893) - R32893 from NSJ Bioreagent

Prices $299.00
Sizes 100 µg (0.5mg/ml if reconstituted with 0.2ml sterile DI water)
Host Rabbit
Clonality Polyclonal
Western blot testing of mouse 1) RAW264.7 and 2) HEPA1-6 cell lysate with Chi3l1 antibody at 0.5ug/ml. Expected molecular weight: 39-43 kDa.

Anti-CHI3L1-Picoband-trade-Antibody - ABO12938 from Abgent, a WuXi AppTec company

Prices $240.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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