Chil1

Gene Symbol	Chil1
Entrez Gene	12654
Alt Symbol	AW208766, Brp39, Chi3l1, Gp39
Species	Mouse
Gene Type	protein-coding
Description	chitinase-like 1
Other Description	CGP-39|GP-39|breast regression protein 39|cartilage glycoprotein 39|chitinase 3-like 1|chitinase-3-like protein 1
Swissprots	Q61362 B0FEU7 Q8BKL8 D3Z2P2 Q99J84 Q3U291 Q4FJW9
Accessions	EDL39625 EDL39626 Q61362 AI853039 AK051475 BAC34654 AK155412 BAE33251 BC003780 AAH03780 BC004734 AAH04734 BC005611 AAH05611 CJ147225 CT010283 CAJ18491 EU313768 ABY53363 X93035 CAA63603 XM_006529111 XP_006529174 XM_006529112 XP_006529175 NM_007695 NP_031721
Function	Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. {ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:19041398, ECO:0000269|PubMed:19414556, ECO:0000269|PubMed:20558631, ECO:00
Subcellular Location	Secreted, extracellular space. Cytoplasm. Endoplasmic reticulum. Note=Detected in bronchoalveolar lavage (BAL) fluids. Localizes mainly to endoplasmic reticulum when overexpressed in cells, with some protein also detected throughout the cytoplasm.
Tissue Specificity	Detected in lung in pulmonary macrophages and alveolar type 2 cells and in bronchoalveolar lavage (BAL) fluids. Expressed in mammary tumor cells (at protein level). Expressed in lung. Not detected in non-inflammatory colon. {ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:19414556, ECO:0000269|PubMed:20558631, ECO:0000269|PubMed:21866546}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Cartilage glycoprotein 39, Mouse, ELISA Kit - E03H0230 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 1.0ng/ml Range 2.5-50ng/mL,

Cartilage glycoprotein 39/YKL40, Mouse, ELISA Kit - E03C0072 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Range 2.5-50ng/ml

Chitinase-3-like protein 1, Chi3l1, Mouse, ELISA Kit - E1463m from ARP American Research Products Category ELISA Kit Prices $496.00 Sizes 96 t Range 0.156-10 ng/ml

Chitinase-3-Like Protein 1, YKL-40/CHI3L1, Mouse, ELISA Kit - YHB0277Mo from ARP American Research Products Category ELISA Kit

Mouse gp-39 ELISA Kit - MH0237 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

YKL-40, ELISA Kit - MBS824898 from MyBioSource Category ELISA Kit Prices $470.00 Sizes 96 tests Sensitivity 10 pg/ml Range 62.5 pg/ml - 4000 pg/ml

Mouse Chitinase 3-like 1 ELISA Kit - DEIA2905 from Creative Diagnostics Category ELISA Kit Sensitivity 6.57 pg/mL Range 2.23 - 16.0 pg/mL

Mouse CHI3L1(Chitinase 3-like 1) ELISA Kit - E-EL-M0016 from Elabscience Category ELISA Kit Sensitivity 37.50 pg/mL Range 62.50—4000 pg/mL

Mouse CHI3L1 (Chitinase 3-like 1) CLIA Kit - E-CL-M0015 from Elabscience Category CLIA Kit Sensitivity 9.38 pg/mL Range Average Recovery (%)

chitinase 3-like 1 (cartilage glycoprotein-39) , ELISA Kit - MBS911948 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.11 ng/ml Range 0.47 ng/ml-30 ng/ml

Chitinase 3-like 1/YKL-40, ELISA Kit - MBS177388 from MyBioSource Category ELISA Kit Prices $425.00 Sizes 1x96 wells Sensitivity < 10pg/ml Range 62.5pg/ml-4000pg/ml

Mouse YKL-40 ELISA Kit - CEK1575 from Cohesion Biosciences Category ELISA Kit Prices $360.00 Sizes 96 t Sensitivity 10 pg/ml Range 62.5 pg/ml - 4000 pg/ml

Mouse Chitinase 3-like 1/YKL-40 PicoKine™ ELISA Kit EK0975 - EK0975 from Boster Bio Category ELISA Kit Prices $369.00 Sizes 1 kit Sensitivity <10pg/ml Range 62.5pg/ml-4000pg/ml *This assay range is determined using common samples. For samples with low target protein concentrations, users can adjust the standard curve to extend the lower limit of assay range.

Mouse Chitinase-3-like protein 1(CHI3L1) ELISA kit - CSB-EL005346MO from Cusabio Category ELISA Kit Sensitivity 0.11ng/ml Range 0.47 ng/ml-30 ng/ml

Mouse Cartilage glycoprotein 39 ELISA - E03H0230 from BlueGene Biotech Category ELISA Kit

Mouse Cartilage glycoprotein 39/YKL40 ELISA - E03C0072 from BlueGene Biotech Category ELISA Kit

Mouse CHI3L1 (Chitinase 3-like 1) CLIA Kit - E-CL-M0015 from Iwai North America Inc. Category CLIA Kit Prices $722.50 Sizes 1 kit Sensitivity 37.5pg/mL Range 62.5-4000pg/mL

CHI3L1 - KBB-570 from Nordic BioSite Sensitivity <10pg/ml Range 62.5pg/ml-4000pg/ml

Mouse Chitinase 3-like 1/YKL-40 ELISA Kit - EA100621 from Acris Antibodies Category ELISA Kit Prices $389.00 Sizes 1 kit Range 10

Chitinase 3-like 1/YKL-40 ELISA Kit (Mouse) (OKBB00480) - OKBB00480 from Aviva Systems Biology Category ELISA Kit Prices $385.00 Sizes 96 wells Sensitivity <= 10 pg/mL Range 62.5 pg/mL-4,000 pg/mL

Mouse Chitinase 3-like 1 ELISA Kit - orb146701 from Biorbyt Category ELISA Kit Prices $612.00 Sizes 96 well Sensitivity < 10pg/ml Range 62.5pg/ml-4000pg/ml

Chi3l1 - EKM0114 from Nordic BioSite Sensitivity 37.5pg/ml Range 62.5-4000pg/ml

Chi3l1 - EKM114 from Nordic BioSite Sensitivity 37.5pg/ml Range 62.5-4000pg/ml

Mouse gp-39/YKL-40 ELISA Kit - E047162 from Biobool Category ELISA Kit

Mouse gp-39 ELISA Kit - E047163 from Biobool Category ELISA Kit

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