| Gene Symbol | Chil1 |
|---|---|
| Entrez Gene | 12654 |
| Alt Symbol | AW208766, Brp39, Chi3l1, Gp39 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | chitinase-like 1 |
| Other Description | CGP-39|GP-39|breast regression protein 39|cartilage glycoprotein 39|chitinase 3-like 1|chitinase-3-like protein 1 |
| Swissprots | Q61362 B0FEU7 Q8BKL8 D3Z2P2 Q99J84 Q3U291 Q4FJW9 |
| Accessions | EDL39625 EDL39626 Q61362 AI853039 AK051475 BAC34654 AK155412 BAE33251 BC003780 AAH03780 BC004734 AAH04734 BC005611 AAH05611 CJ147225 CT010283 CAJ18491 EU313768 ABY53363 X93035 CAA63603 XM_006529111 XP_006529174 XM_006529112 XP_006529175 NM_007695 NP_031721 |
| Function | Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. {ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:19041398, ECO:0000269|PubMed:19414556, ECO:0000269|PubMed:20558631, ECO:00 |
| Subcellular Location | Secreted, extracellular space. Cytoplasm. Endoplasmic reticulum. Note=Detected in bronchoalveolar lavage (BAL) fluids. Localizes mainly to endoplasmic reticulum when overexpressed in cells, with some protein also detected throughout the cytoplasm. |
| Tissue Specificity | Detected in lung in pulmonary macrophages and alveolar type 2 cells and in bronchoalveolar lavage (BAL) fluids. Expressed in mammary tumor cells (at protein level). Expressed in lung. Not detected in non-inflammatory colon. {ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:19414556, ECO:0000269|PubMed:20558631, ECO:0000269|PubMed:21866546}. |