Gene Symbol | CST5 |
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Entrez Gene | 1473 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | cystatin D |
Other Description | cystatin 5|cystatin-5|cystatin-D|cysteine-proteinase inhibitor |
Swissprots | Q5JRF5 Q9UCA0 P28325 |
Accessions | CAA42590 EAX10132 P28325 BC062678 AAH62678 BC069514 AAH69514 CB985957 HQ447459 ADQ31945 X70377 CAA49838 NM_001900 NP_001891 |
Function | Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B. {ECO:0000269|PubMed:8083219}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:20189825}. |
Tissue Specificity | Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in parotid gland but not in seminal vesicle, prostate, epididymis, testis, ovary, placenta, thyroid, gastric corpus, small intestine, liver, or gall bladder tissue. {ECO:0000269|PubMed:20189825}. |
Top Pathways | Salivary secretion |
cystatin D CRISPR/Cas9 KO Plasmid (h) - sc-405049 from Santa Cruz Biotechnology
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cystatin D HDR Plasmid (h) - sc-405049-HDR from Santa Cruz Biotechnology
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cystatin D Double Nickase Plasmid (h) - sc-405049-NIC from Santa Cruz Biotechnology
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cystatin D Double Nickase Plasmid (h2) - sc-405049-NIC-2 from Santa Cruz Biotechnology
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cystatin D CRISPR Activation Plasmid (h) - sc-405049-ACT from Santa Cruz Biotechnology
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cystatin D CRISPR Activation Plasmid (h2) - sc-405049-ACT-2 from Santa Cruz Biotechnology
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cystatin D Lentiviral Activation Particles (h) - sc-405049-LAC from Santa Cruz Biotechnology
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cystatin D Lentiviral Activation Particles (h2) - sc-405049-LAC-2 from Santa Cruz Biotechnology
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cystatin D siRNA (h) - sc-60489 from Santa Cruz Biotechnology
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cystatin D shRNA Plasmid (h) - sc-60489-SH from Santa Cruz Biotechnology
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cystatin D shRNA (h) Lentiviral Particles - sc-60489-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU010481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6674 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6674 from Sigma-Aldrich
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CST5 siRNA (Human) - CRH1041 from Cohesion Biosciences
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CST5 - MBS8219848 from MyBioSource
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shRNA set against Human CST5 (NM_001900.4) - SHH270757 from Creative biogene
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Human CST5 siRNA - orb261543 from Biorbyt
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CST5 shRNA Plasmid (Human) - CHH1041 from Cohesion Biosciences
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CST5 miRNA 3'UTR clone - MiUTR1H-02495 from Creative biogene
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