Gene Symbol | TNFRSF14 |
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Entrez Gene | 8764 |
Alt Symbol | ATAR, CD270, HVEA, HVEM, LIGHTR, TR2 |
Species | Human |
Gene Type | protein-coding |
Description | tumor necrosis factor receptor superfamily, member 14 |
Other Description | CD40-like protein|herpes virus entry mediator A|tumor necrosis factor receptor superfamily member 14|tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)|tumor necrosis factor receptor-like gene2 |
Swissprots | Q9UM65 B9DI89 B3KW30 Q96J31 Q8N634 Q6IB95 Q8WXR1 Q92956 |
Accessions | AAR23264 EAW56089 EAW56090 EAW56091 EAW56092 EAW56093 EAW56094 Q92956 AB208808 BAD92045 AF153978 AAF75588 AF373877 AAL47717 AF373878 AAL47718 AK124010 BAG53992 AK130172 BAC85297 AK300515 BAG62227 AK303468 BAG64508 AK310076 AY358879 AAQ89238 BC002794 AAH02794 BC018882 BC029848 AAH29848 BM981793 BX343044 CD366981 CR456909 CAG33190 DC383433 DQ893000 ABM83926 DQ896755 ABM87754 U70321 AAB58354 U81232 AAD00505 XM_006711019 XP_006711082 XM_006711020 XP_006711083 XM_006724947 XP_006725010 XM_006724948 XP_006725011 XM_011542383 XP_011540685 XM_011546411 XP_011544713 XR_426638 XR_430632 NM_001297605 NP_001284534 NM_003820 NP_003811 |
Function | Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells. {ECO:0000269|PubMed:8898196}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
Tissue Specificity | Widely expressed, with the highest expression in lung, spleen and thymus. |
Top Pathways | Cytokine-cytokine receptor interaction, Herpes simplex infection |
Active human TNFRSF14 protein fragment - ab155629 from Abcam
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Active human TNFRSF14 protein fragment - ab198632 from Abcam
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Active human TNFRSF14 protein fragment - ab56291 from Abcam
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Human TNFRSF14 protein fragment - ab134892 from Abcam
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Human TNFRSF14 protein fragment - ab174419 from Abcam
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TNFRSF14 peptide (240-251) - ab45834 from Abcam
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TNFRSF14 / CD270 / HVEM Antibody Blocking Peptide - LS-E30226 from LifeSpan Bioscience
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TNFRSF14 / CD270 / HVEM Antibody Blocking Peptide - LS-E30225 from LifeSpan Bioscience
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TNFRSF14 / CD270 / HVEM Antibody Blocking Peptide - LS-E25170 from LifeSpan Bioscience
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TNFRSF14 / CD270 / HVEM Antibody Blocking Peptide - LS-E25991 from LifeSpan Bioscience
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TNFRSF14 / CD270 / HVEM Antibody Blocking Peptide - LS-E9936 from LifeSpan Bioscience
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HVEM/TNFRSF14 Recombinant Protein - H00008764-P01 from Novus Biologicals
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Recombinant Human HVEM/TNFRSF14 Protein - NBP2-22904 from Novus Biologicals
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HVEM/TNFRSF14 Blocking Peptide - NBP1-76690PEP from Novus Biologicals
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HVEM/TNFRSF14 Blocking Peptide - NBP1-76689PEP from Novus Biologicals
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HVEM/TNFRSF14 Recombinant Protein - H00008764-G01 from Novus Biologicals
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TNFRSF14-Antibody-Center-Blocking-Peptide - BP9094c from Abgent, a WuXi AppTec company
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HVEM-Fc Recombinant Protein (Active) - GTX48107-PRO from GeneTex
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Recombinant Human HVEM/TNFRSF14 Fc Chimera - 356-HV-100 from R&D Systems
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Recombinant Human HVEM/TNFRSF14 Fc Chimera, CF - 356-HV-100/CF from R&D Systems
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Cynomolgus TNFRSF14 protein - orb139771 from Biorbyt
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Human TNFRSF14 His tag protein - orb84016 from Biorbyt
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Human TNFRSF14 Fc His tag protein - orb83020 from Biorbyt
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Mouse TNFRSF14 Fc His tag protein - orb83660 from Biorbyt
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HVEM-Fc protein - 30R-AH072 from Fitzgerald
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