| Gene Symbol |
ZGPAT
|
| Entrez Gene |
84619
|
| Alt Symbol |
GPATC6, GPATCH6, KIAA1847, ZC3H9, ZC3HDC9, ZIP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger, CCCH-type with G patch domain
|
| Other Description |
g patch domain-containing protein 6|zinc finger CCCH domain-containing protein 9|zinc finger CCCH-type with G patch domain-containing protein|zinc finger and G patch domain-containing protein
|
| Swissprots |
E1P5K1 Q8N5A5 Q5JWI9 Q96JI0 Q96JU4 Q9H401 Q5JWJ0 Q8NC55 Q4VXN9 Q8WUV4
|
| Accessions |
EAW75220 EAW75221 EAW75222 EAW75223 EAW75224 EAW75225 EAW75226 EAW75227 EAW75228 EAW75229 Q8N5A5 AB058750 BAB47476 AK027878 BAB55426 AK074961 BAC11317 AK307368 AK314726 BC019338 AAH19338 BC032612 AAH32612 CV027894 DA055150 DA252406 DA848516 DB025637 HQ448238 ADQ32718 NM_181484 NM_001083113 NP_001076582 NM_001195653 NP_001182582 NM_001195654 NP_001182583 NM_032527 NP_115916 NM_181485 NP_852150
|
| Function |
Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. {ECO:0000269|PubMed:19644445}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19644445}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:19644445}.
|