| Gene Symbol |
RRAGC
|
| Entrez Gene |
64121
|
| Alt Symbol |
GTR2, RAGC, TIB929
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Ras-related GTP binding C
|
| Other Description |
GTPase-interacting protein 2|Rag C protein|ras-related GTP-binding protein C
|
| Swissprots |
Q9H202 Q9H8Q8 Q9HB90
|
| Accessions |
EAX07293 EAX07294 Q9HB90 AF131773 AF272035 AAG32662 AF323609 AAG45221 AK023373 BAB14548 AK092808 AK298573 BAG60765 AK298788 BAG60926 AK315791 AW327252 BC016668 AAH16668 BG717489 BI461665 BQ003663 CA449149 CB132041 CX761032 DQ891734 ABM82660 DQ894911 ABM85837 ES308561 HY202961 HY264464 NM_001271851 NP_001258780 NM_022157 NP_071440
|
| Function |
Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. {ECO:0000269|PubMed:20381137}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA.
|
| Top Pathways |
mTOR signaling pathway
|
![Western Blot: RRAGC Overexpression Lysate (Adult Normal) [NBL1-15587] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RRAGC.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3877_RRAGC%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15587-img0002.jpg)