| Gene Symbol |
USP19
|
| Entrez Gene |
10869
|
| Alt Symbol |
ZMYND9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 19
|
| Other Description |
deubiquitinating enzyme 19|ubiquitin carboxyl-terminal hydrolase 19|ubiquitin specific protease 19|ubiquitin thioesterase 19|ubiquitin thiolesterase 19|ubiquitin-specific-processing protease 19|zinc finger MYND domain-containing protein 9
|
| Swissprots |
A6H8U2 Q86XV9 Q641Q9 B4DTZ0 A5PKX8 Q6NZY8 E7EN22 B4DGT3 O94966 E9PEG8 Q3KQW4 E7ETS0
|
| Accessions |
EAW64955 EAW64956 EAW64957 O94966 AB020698 BAA74914 AK294756 BAG57894 AK296447 BAG59098 AK300425 BAG62152 BC014934 BC048269 AAH48269 BC065909 AAH65909 BC082241 AAH82241 BC106029 AAI06030 BC128088 BC142660 AAI42661 BC142727 AAI42728 BC146752 AAI46753 DC323791 DC332671 EF036501 ABO65087 XM_005264823 XP_005264880 XM_005264824 XP_005264881 XM_005264825 XP_005264882 XM_005264826 XP_005264883 XM_005264827 XP_005264884 XM_005264829 XP_005264886 XM_005264830 XP_005264887 XM_005264831 XP_005264888 XM_006712946 XP_006713009 XM_006712947 XP_006713010 XM_006712948 XP_006713011 XM_006712949 XP_006713012 XM_006712950 XP_006713013 XM_006712951 XP_006713014 XM_006712952 XP_006713015 XM_006712953 XP_006713016 NM_001199160 NP_001186089 NM_001199161 NP_001186090 NM_001199162 NP_001186091 NM_006677 NP_006668
|
| Function |
Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin- dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic- reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non- catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains. {ECO:0000269|PubMed:19465887, ECO:0000269|PubMed:21849505, ECO
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:19465887}; Single-pass membrane protein {ECO:0000269|PubMed:19465887}.
|