USP19

Gene Symbol USP19
Entrez Gene 10869
Alt Symbol ZMYND9
Species Human
Gene Type protein-coding
Description ubiquitin specific peptidase 19
Other Description deubiquitinating enzyme 19|ubiquitin carboxyl-terminal hydrolase 19|ubiquitin specific protease 19|ubiquitin thioesterase 19|ubiquitin thiolesterase 19|ubiquitin-specific-processing protease 19|zinc finger MYND domain-containing protein 9
Swissprots A6H8U2 Q86XV9 Q641Q9 B4DTZ0 A5PKX8 Q6NZY8 E7EN22 B4DGT3 O94966 E9PEG8 Q3KQW4 E7ETS0
Accessions EAW64955 EAW64956 EAW64957 O94966 AB020698 BAA74914 AK294756 BAG57894 AK296447 BAG59098 AK300425 BAG62152 BC014934 BC048269 AAH48269 BC065909 AAH65909 BC082241 AAH82241 BC106029 AAI06030 BC128088 BC142660 AAI42661 BC142727 AAI42728 BC146752 AAI46753 DC323791 DC332671 EF036501 ABO65087 XM_005264823 XP_005264880 XM_005264824 XP_005264881 XM_005264825 XP_005264882 XM_005264826 XP_005264883 XM_005264827 XP_005264884 XM_005264829 XP_005264886 XM_005264830 XP_005264887 XM_005264831 XP_005264888 XM_006712946 XP_006713009 XM_006712947 XP_006713010 XM_006712948 XP_006713011 XM_006712949 XP_006713012 XM_006712950 XP_006713013 XM_006712951 XP_006713014 XM_006712952 XP_006713015 XM_006712953 XP_006713016 NM_001199160 NP_001186089 NM_001199161 NP_001186090 NM_001199162 NP_001186091 NM_006677 NP_006668
Function Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin- dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic- reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non- catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains. {ECO:0000269|PubMed:19465887, ECO:0000269|PubMed:21849505, ECO
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:19465887}; Single-pass membrane protein {ECO:0000269|PubMed:19465887}.

USP19 CRISPR/Cas9 KO Plasmid (h) - sc-406063 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP19 HDR Plasmid (h) - sc-406063-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP19 Double Nickase Plasmid (h) - sc-406063-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP19 Double Nickase Plasmid (h2) - sc-406063-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP19 CRISPR Activation Plasmid (h) - sc-406063-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP19 CRISPR Activation Plasmid (h2) - sc-406063-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP19 Lentiviral Activation Particles (h) - sc-406063-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP19 Lentiviral Activation Particles (h2) - sc-406063-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP19 siRNA (h) - sc-78424 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

USP19 shRNA Plasmid (h) - sc-78424-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

USP19 shRNA (h) Lentiviral Particles - sc-78424-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU075841 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22567 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22567 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01702 from Sigma-Aldrich

Category miRNA

USP19 siRNA (Human) - CRH7402 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

USP19 RNAi - H00010869-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

USP19 - MBS8225645 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Usp19 (NM_006677.2) - SHH441328 from Creative biogene

Category siRNA
Species Reactivities Human

Human USP19 siRNA - orb267904 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

USP19 shRNA Plasmid (Human) - CHH7402 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

USP19 miRNA 3'UTR clone - MiUTR3H-13264 from Creative biogene

Species Reactivities Human
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