Gene Symbol | ERCC1 |
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Entrez Gene | 2067 |
Alt Symbol | COFS4, RAD10, UV20 |
Species | Human |
Gene Type | protein-coding |
Description | excision repair cross-complementation group 1 |
Other Description | DNA excision repair protein ERCC-1|excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) |
Swissprots | Q96S40 P07992 B2RC01 Q7Z7F5 B3KRR0 |
Accessions | AAA52395 AAM34796 EAW57348 EAW57349 EAW57350 P07992 AA761510 AB069681 BAB62810 AF001925 AAC16253 AF433652 AAL56574 AK092039 BAG52472 AK314884 BAG37398 BC008930 AAH08930 BC052813 AAH52813 BM011724 BM450988 BM789972 BQ019990 BQ671113 BT019806 AAV38609 BU627436 DB468563 DQ586988 DQ893002 ABM83928 DQ896248 ABM87247 M13194 AAA52394 M28650 AAA35810 S94539 AAD14434 XM_005258634 XP_005258691 XM_005258635 XP_005258692 XM_005258636 XP_005258693 XM_005258637 XP_005258694 XM_011526610 XP_011524912 NM_001166049 NP_001159521 NM_001983 NP_001974 NM_202001 NP_973730 |
Function | Isoform 1: Non-catalytic component of a structure- specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. |
Subcellular Location | Isoform 3: Nucleus. |
Top Pathways | Nucleotide excision repair, Fanconi anemia pathway |
ERCC1 peptide - ab93790 from Abcam
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Human ERCC1 full length protein - ab83630 from Abcam
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Human ERCC1 protein fragment - ab126690 from Abcam
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ERCC1 Antibody Blocking Peptide - LS-E2975 from LifeSpan Bioscience
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ERCC1 Antibody Blocking Peptide - LS-E26532 from LifeSpan Bioscience
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ERCC1 Antibody Blocking Peptide - LS-E26662 from LifeSpan Bioscience
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ERCC1 Antibody Blocking Peptide - LS-E20253 from LifeSpan Bioscience
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ERCC1 Recombinant Protein - H00002067-P01 from Novus Biologicals
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ERCC1 Partial Recombinant Protein - H00002067-Q01 from Novus Biologicals
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Recombinant Human ERCC1 Protein - NBP1-98981 from Novus Biologicals
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ERCC1-Antibody-C-term-Blocking-peptide - BP14106b from Abgent, a WuXi AppTec company
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ERCC1 blocking peptide - GTX88627-PEP from GeneTex
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Human ERCC1 protein - orb168310 from Biorbyt
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Human ERCC1 protein (GST Tag) - orb81089 from Biorbyt
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ERCC1 Immunizing peptide - orb50495 from Biorbyt
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Ercc1 Blocking Peptide - 33R-4759 from Fitzgerald
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ERCC1 protein (His tag) - 80R-2286 from Fitzgerald
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ERCC1 Blocking Peptide - abx062590 from Abbexa
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ERCC1 Peptide - AC21-1368-P from Abcore
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ERCC1 (1-273, His-tag) - AR50370PU-N from Acris Antibodies
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ERCC1 (1-273, His-tag) - AR50370PU-S from Acris Antibodies
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ERCC1 - H00002067-P01 from Acris Antibodies
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ERCC1 - H00002067-P01-10 from Acris Antibodies
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ERCC1 - H00002067-Q01-10 from Acris Antibodies
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ERCC1 - H00002067-Q01-25 from Acris Antibodies
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