| Gene Symbol |
UGT1A7
|
| Entrez Gene |
54577
|
| Alt Symbol |
UDPGT, UDPGT 1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
UDP glucuronosyltransferase 1 family, polypeptide A7
|
| Other Description |
UDP glycosyltransferase 1 family, polypeptide A7|UDP-glucuronosyltransferase 1 family polypeptide A7s|UDP-glucuronosyltransferase 1-7|UDP-glucuronosyltransferase 1-G|UDP-glucuronosyltransferase 1A7
|
| Swissprots |
Q9HAW7 O00473 B8K293
|
| Accessions |
AAA80548 AAG30419 AAG43194 AAG43195 AAG43196 AAK97173 AAK97174 AAK97175 AAQ04300 AAQ04301 AAQ04478 AAQ04806 AAQ07456 CAL32687 Q9HAW7 AY435142 AAR95643 BC001521 AAH01521 BC146418 AAI46419 BC153172 AAI53173 DQ383513 ABD42926 U89507 AAB81536 NM_019077 NP_061950
|
| Function |
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:23360619}.
|
| Subcellular Location |
Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Liver and gastric tissue. Isoform 1 and isoform 2 are expressed in esophagus. Neither isoform is expressed in liver, kidney, colon and small intestine (PubMed:18004212). {ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:9271343}.
|
| Top Pathways |
Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450
|