Gene Symbol | UGT1A7 |
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Entrez Gene | 54577 |
Alt Symbol | UDPGT, UDPGT 1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G |
Species | Human |
Gene Type | protein-coding |
Description | UDP glucuronosyltransferase 1 family, polypeptide A7 |
Other Description | UDP glycosyltransferase 1 family, polypeptide A7|UDP-glucuronosyltransferase 1 family polypeptide A7s|UDP-glucuronosyltransferase 1-7|UDP-glucuronosyltransferase 1-G|UDP-glucuronosyltransferase 1A7 |
Swissprots | Q9HAW7 O00473 B8K293 |
Accessions | AAA80548 AAG30419 AAG43194 AAG43195 AAG43196 AAK97173 AAK97174 AAK97175 AAQ04300 AAQ04301 AAQ04478 AAQ04806 AAQ07456 CAL32687 Q9HAW7 AY435142 AAR95643 BC001521 AAH01521 BC146418 AAI46419 BC153172 AAI53173 DQ383513 ABD42926 U89507 AAB81536 NM_019077 NP_061950 |
Function | UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:23360619}. |
Subcellular Location | Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Liver and gastric tissue. Isoform 1 and isoform 2 are expressed in esophagus. Neither isoform is expressed in liver, kidney, colon and small intestine (PubMed:18004212). {ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:9271343}. |
Top Pathways | Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450 |
UGT1A7 CRISPR/Cas9 KO Plasmid (h) - sc-418245 from Santa Cruz Biotechnology
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UGT1A7 HDR Plasmid (h) - sc-418245-HDR from Santa Cruz Biotechnology
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UGT1A7 Double Nickase Plasmid (h) - sc-418245-NIC from Santa Cruz Biotechnology
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UGT1A7 Double Nickase Plasmid (h2) - sc-418245-NIC-2 from Santa Cruz Biotechnology
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UGT1A7 CRISPR Activation Plasmid (h) - sc-418245-ACT from Santa Cruz Biotechnology
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UGT1A7 CRISPR Activation Plasmid (h2) - sc-418245-ACT-2 from Santa Cruz Biotechnology
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UGT1A7 Lentiviral Activation Particles (h) - sc-418245-LAC from Santa Cruz Biotechnology
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UGT1A7 Lentiviral Activation Particles (h2) - sc-418245-LAC-2 from Santa Cruz Biotechnology
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UGT1A7 siRNA (h) - sc-44475 from Santa Cruz Biotechnology
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UGT1A7 shRNA Plasmid (h) - sc-44475-SH from Santa Cruz Biotechnology
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UGT1A7 shRNA (h) Lentiviral Particles - sc-44475-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN22462 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22462 from Sigma-Aldrich
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UGT1A7 siRNA (Human) - CRJ0142 from Cohesion Biosciences
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UGT1A7 - MBS8220733 from MyBioSource
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shRNA set against Human UGT1A7 (NM_019077.2) - SHH440109 from Creative biogene
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shRNA set against Human UGT1A7(NM_019077.2) - SHL113284 from Creative biogene
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UGT1A7 shRNA Plasmid (Human) - CHJ0142 from Cohesion Biosciences
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UGT1A7 miRNA 3'UTR clone - MiUTR1H-10993 from Creative biogene
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