| Gene Symbol | ARL6 |
|---|---|
| Entrez Gene | 84100 |
| Alt Symbol | BBS3, RP55 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ADP-ribosylation factor-like 6 |
| Other Description | ADP-ribosylation factor-like protein 6|Bardet-Biedl syndrome 3 protein |
| Swissprots | Q9H0F7 D3DN31 A8KA93 |
| Accessions | EAW79880 EAW79881 EAW79882 EAW79883 EAW79884 Q9H0F7 AK292958 BAF85647 AK310829 AK311281 AL136815 CAB66749 AL138043 AM392662 CAL37540 AM393355 CAL38233 BC024239 AAH24239 BG722744 BM705017 BU183949 BU607306 DC323603 XM_006713779 XP_006713842 XM_006713783 XP_006713846 XM_011513230 XP_011511532 XR_924184 XR_924185 XR_924186 XR_924187 XR_924188 XR_924189 NM_001278293 NP_001265222 NM_032146 NP_115522 NM_177976 NP_816931 NR_103511 |
| Function | Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia (PubMed:20603001). Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (By similarity). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation (PubMed:22072986). May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade (PubMed:20207729). Isoform 2 may be required for proper retinal function and organization (By similarity). {ECO:0000250|UniProtKB:O88848, ECO:0000269|PubMed:20207729, ECO:0000269|PubMed:20603001, ECO:0000269|PubMed:22072986}. |
| Subcellular Location | Cell projection, cilium membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Note=Appears in a pattern of punctae flanking the microtubule axoneme that likely correspond to small membrane-associated patches. Localizes to the so-called ciliary gate where vesicles carrying ciliary cargo fuse with the membrane. |
BBS3 CRISPR/Cas9 KO Plasmid (h) - sc-407246 from Santa Cruz Biotechnology
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BBS3 HDR Plasmid (h) - sc-407246-HDR from Santa Cruz Biotechnology
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BBS3 Double Nickase Plasmid (h) - sc-407246-NIC from Santa Cruz Biotechnology
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BBS3 Double Nickase Plasmid (h2) - sc-407246-NIC-2 from Santa Cruz Biotechnology
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BBS3 CRISPR Activation Plasmid (h) - sc-407246-ACT from Santa Cruz Biotechnology
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BBS3 CRISPR Activation Plasmid (h2) - sc-407246-ACT-2 from Santa Cruz Biotechnology
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BBS3 Lentiviral Activation Particles (h) - sc-407246-LAC from Santa Cruz Biotechnology
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BBS3 Lentiviral Activation Particles (h2) - sc-407246-LAC-2 from Santa Cruz Biotechnology
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BBS3 siRNA (h) - sc-60253 from Santa Cruz Biotechnology
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BBS3 shRNA Plasmid (h) - sc-60253-SH from Santa Cruz Biotechnology
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BBS3 shRNA (h) Lentiviral Particles - sc-60253-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU099531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3496 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3496 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05320 from Sigma-Aldrich
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ARL6 siRNA (Human) - CRJ3298 from Cohesion Biosciences
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ARL6 - MBS8206243 from MyBioSource
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shRNA set against Human ARL6 (NM_177976.1) - SHH240274 from Creative biogene
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shRNA set against Human ARL6(NM_032146.3) - SHG072921 from Creative biogene
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Human ARL6 siRNA - orb273799 from Biorbyt
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ARL6 shRNA Plasmid (Human) - CHJ3298 from Cohesion Biosciences
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ARL6 miRNA 3'UTR clone - MiUTR1H-00571 from Creative biogene
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ARL6 miRNA 3'UTR clone - MiUTR3H-10265 from Creative biogene
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