| Gene Symbol |
CDYL
|
| Entrez Gene |
9425
|
| Alt Symbol |
CDYL1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chromodomain protein, Y-like
|
| Other Description |
CDY-like, autosomal|chromodomain Y-like protein|testis-specific chromodomain Y-like protein
|
| Swissprots |
Q5VX99 Q9Y232 Q9BWZ2 B4DLG4 Q0VDG7 Q32NC5 Q9Y424 Q6P7T5 A8K6D6
|
| Accessions |
EAW55168 Q9Y232 AF081258 AAD22734 AF081259 AAD22735 AK291601 BAF84290 AK296985 BAG59526 AL050164 CAB43304 BC043397 BC061516 AAH61516 BC108725 AAI08726 BC119682 AAI19683 BE874176 BG766689 BQ930016 BU752976 XM_011514997 XP_011513299 NM_001143970 NP_001137442 NM_001143971 NP_001137443 NM_004824 NP_004815 NR_026590 NM_170752
|
| Function |
Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Has histone acetyltransferase activity, with a preference for histone H4. {ECO:0000269|PubMed:12072557, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:22009739}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:18450745, ECO:0000269|PubMed:19808672}.
|
| Tissue Specificity |
Ubiquitous. Expressed at moderate levels in all tissues examined. Isoform 2 is the most abundantly expressed isoform. {ECO:0000269|PubMed:19808672}.
|
![Western Blot: CDYL Overexpression Lysate (Adult Normal) [NBP2-05204] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CDYL.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/24357_CDYL%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-05204-img0001.jpg)
![Western Blot: CDYL Overexpression Lysate (Adult Normal) [NBP2-05203] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CDYL.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5365_CDYL%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05203-img0001.jpg)