Gene Symbol | CDYL |
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Entrez Gene | 9425 |
Alt Symbol | CDYL1 |
Species | Human |
Gene Type | protein-coding |
Description | chromodomain protein, Y-like |
Other Description | CDY-like, autosomal|chromodomain Y-like protein|testis-specific chromodomain Y-like protein |
Swissprots | Q5VX99 Q9Y232 Q9BWZ2 B4DLG4 Q0VDG7 Q32NC5 Q9Y424 Q6P7T5 A8K6D6 |
Accessions | EAW55168 Q9Y232 AF081258 AAD22734 AF081259 AAD22735 AK291601 BAF84290 AK296985 BAG59526 AL050164 CAB43304 BC043397 BC061516 AAH61516 BC108725 AAI08726 BC119682 AAI19683 BE874176 BG766689 BQ930016 BU752976 XM_011514997 XP_011513299 NM_001143970 NP_001137442 NM_001143971 NP_001137443 NM_004824 NP_004815 NR_026590 NM_170752 |
Function | Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Has histone acetyltransferase activity, with a preference for histone H4. {ECO:0000269|PubMed:12072557, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:22009739}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:18450745, ECO:0000269|PubMed:19808672}. |
Tissue Specificity | Ubiquitous. Expressed at moderate levels in all tissues examined. Isoform 2 is the most abundantly expressed isoform. {ECO:0000269|PubMed:19808672}. |
Human CDYL full length protein - ab131941 from Abcam
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Human CDYL protein fragment - ab152984 from Abcam
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Mouse CDYL peptide - ab13740 from Abcam
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CDYL Antibody Blocking Peptide - LS-E4328 from LifeSpan Bioscience
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CDYL Antibody Blocking Peptide - LS-E25479 from LifeSpan Bioscience
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CDYL Antibody Blocking Peptide - LS-E17761 from LifeSpan Bioscience
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Recombinant Human CDYL Protein - H00009425-Q01 from Novus Biologicals
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CDYL Recombinant Protein - H00009425-P01 from Novus Biologicals
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CDYL-Antibody-N-term-Blocking-Peptide - BP16624a from Abgent, a WuXi AppTec company
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CDYL blocking peptide - GTX89858-PEP from GeneTex
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CDYL Blocking Peptide - 33R-10137 from Fitzgerald
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CDYL Peptide - AC21-0308-P from Abcore
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CDYL - H00009425-P01-10 from Acris Antibodies
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CDYL - H00009425-P01-25 from Acris Antibodies
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CDYL - H00009425-Q01-10 from Acris Antibodies
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CDYL - H00009425-Q01-25 from Acris Antibodies
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CDYL Peptide - 45-035P from ProSci
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CDYL fusion protein - ag12143 from Proteintech Group
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CDYL fusion protein - ag12387 from Proteintech Group
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Recombinant Human Chromodomain Y-like protein(CDYL) - CSB-YP896685HU CSB-EP896685HU CSB-BP896685HU CSB-MP896685HU from Cusabio
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CDYL, Peptide - MBS426104 from MyBioSource
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CDYL Recombinant Protein Antigen - NBP2-34011PEP from Novus Biologicals
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CDYL Antibody - SH-A10994 from Novatein Biosciences
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CDYL Peptide, Human - M34GP02922H from Creative Peptides
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Chromodomain Y-like protein (CDYL), Recombinant Protein - MBS1335511 from MyBioSource
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