Gene Symbol | CDYL |
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Entrez Gene | 9425 |
Alt Symbol | CDYL1 |
Species | Human |
Gene Type | protein-coding |
Description | chromodomain protein, Y-like |
Other Description | CDY-like, autosomal|chromodomain Y-like protein|testis-specific chromodomain Y-like protein |
Swissprots | Q5VX99 Q9Y232 Q9BWZ2 B4DLG4 Q0VDG7 Q32NC5 Q9Y424 Q6P7T5 A8K6D6 |
Accessions | EAW55168 Q9Y232 AF081258 AAD22734 AF081259 AAD22735 AK291601 BAF84290 AK296985 BAG59526 AL050164 CAB43304 BC043397 BC061516 AAH61516 BC108725 AAI08726 BC119682 AAI19683 BE874176 BG766689 BQ930016 BU752976 XM_011514997 XP_011513299 NM_001143970 NP_001137442 NM_001143971 NP_001137443 NM_004824 NP_004815 NR_026590 NM_170752 |
Function | Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Has histone acetyltransferase activity, with a preference for histone H4. {ECO:0000269|PubMed:12072557, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:22009739}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:18450745, ECO:0000269|PubMed:19808672}. |
Tissue Specificity | Ubiquitous. Expressed at moderate levels in all tissues examined. Isoform 2 is the most abundantly expressed isoform. {ECO:0000269|PubMed:19808672}. |
CDYL CRISPR/Cas9 KO Plasmid (h) - sc-406624 from Santa Cruz Biotechnology
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CDYL HDR Plasmid (h) - sc-406624-HDR from Santa Cruz Biotechnology
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CDYL Double Nickase Plasmid (h) - sc-406624-NIC from Santa Cruz Biotechnology
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CDYL Double Nickase Plasmid (h2) - sc-406624-NIC-2 from Santa Cruz Biotechnology
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CDYL CRISPR Activation Plasmid (h) - sc-406624-ACT from Santa Cruz Biotechnology
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CDYL CRISPR Activation Plasmid (h2) - sc-406624-ACT-2 from Santa Cruz Biotechnology
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CDYL Lentiviral Activation Particles (h) - sc-406624-LAC from Santa Cruz Biotechnology
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CDYL Lentiviral Activation Particles (h2) - sc-406624-LAC-2 from Santa Cruz Biotechnology
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CDYL siRNA (h) - sc-45271 from Santa Cruz Biotechnology
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CDYL shRNA Plasmid (h) - sc-45271-SH from Santa Cruz Biotechnology
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CDYL shRNA (h) Lentiviral Particles - sc-45271-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU086051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5894 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5894 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09425 from Sigma-Aldrich
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CDYL siRNA (Human) - CRH6251 from Cohesion Biosciences
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CDYL - MBS8222287 from MyBioSource
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shRNA set against Human CDYL (NM_004824.3) - SHH261121 from Creative biogene
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CDYL shRNA Plasmid (Human) - CHH6251 from Cohesion Biosciences
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CDYL miRNA 3'UTR clone - MiUTR3H-06264 from Creative biogene
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CDYL miRNA 3'UTR clone - MiUTR3H-06265 from Creative biogene
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CDYL miRNA 3'UTR clone - MiUTR3H-06266 from Creative biogene
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