HCAR1

Gene Symbol HCAR1
Entrez Gene 27198
Alt Symbol FKSG80, GPR104, GPR81, HCA1, LACR1, TA-GPCR, TAGPCR
Species Human
Gene Type protein-coding
Description hydroxycarboxylic acid receptor 1
Other Description G protein-coupled receptor 104|G protein-coupled receptor 81|G-protein coupled receptor 104|G-protein coupled receptor 81|T-cell activation G protein-coupled receptor|hydroxy-carboxylic acid receptor 1|lactate receptor 1
Swissprots B2R9X4 Q9BXC0 Q6NXU5 Q3Y5J3 Q4VBN1
Accessions AAL26481 AAZ67915 BAB89344 BAC06084 EAW98337 Q9BXC0 AF345568 AAK29071 AF385431 AAM43832 AF385432 AAM43833 AK122659 AK289557 BAF82246 AK313955 BAG36671 AY507143 AAR92485 BC066881 AAH66881 BC066882 AAH66882 BC066883 AAH66883 BC067484 AAH67484 BC095506 AAH95506 EU809458 ACJ03844 GQ129267 ACT64401 GQ129268 ACT64402 NM_032554 NP_115943
Function Acts as a receptor for L-lactate and mediates its anti- lipolytic effect through a G(i)-protein-mediated pathway. {ECO:0000269|PubMed:19047060}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Expressed abundantly in brown and white fat. It also detectable at lower levels in liver, kidney, skeletal muscle, brain and pituitary. Not detected in frontal, temporal and occipital lobes of the cortex, basal forebrain, caudate nucleus, nucleus accumbens and hippocampus. {ECO:0000269|PubMed:11574155, ECO:0000269|PubMed:19047060}.
Top Pathways cAMP signaling pathway

FKSG80 (T-16) - sc-32647 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FKSG80 (T-16): sc-32647. Western blot analysis of FKSG80 expression in T24 whole cell lysate.

FKSG80 (C-16) - sc-32648 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-GPCR GPR81 antibody - ab124010 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-GPCR GPR81 antibody (ab124010) at 1/100 dilution + 293 cell line lysate at 35 µg

Anti-GPCR GPR81 antibody - ab106942 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-GPCR GPR81 antibody (ab106942) at 0.5 µg/ml + Human liver lysate at 35 µgdeveloped using the ECL technique

Anti-GPCR GPR81 antibody - C-terminal - ab188647 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of Formalin-Fixed, Paraffin-Embedded Human anterior pituitary tissue labelling GPCR GPR81 with ab188647 at 20 µg/ml.

Anti-FKSG80 / GPR81 Antibody (Ser296, APC) - LS-C243938 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FKSG80 / GPR81 Antibody (Cys7, AP) - LS-C243941 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-FKSG80 / GPR81 Antibody (Cys7, APC) - LS-C243942 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-FKSG80 / GPR81 Antibody (Ser296, Biotin) - LS-C243940 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FKSG80 / GPR81 Antibody (Cys7, FITC) - LS-C243944 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-FKSG80 / GPR81 Antibody (Cys7, Biotin) - LS-C243943 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-FKSG80 / GPR81 Antibody (Cys7, PE) - LS-C243945 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-FKSG80 / GPR81 Antibody (Ser296, FITC) - LS-C243946 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FKSG80 / GPR81 Antibody (Arg203, APC) - LS-C243948 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-FKSG80 / GPR81 Antibody (Arg203, AP) - LS-C243947 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-FKSG80 / GPR81 Antibody (Arg203, Biotin) - LS-C243949 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-FKSG80 / GPR81 Antibody (aa287-316) - LS-C166640 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
GPR81 Antibody western blot of 293 cell line lysates (35 ug/lane). The GPR81 antibody detected the GPR81 protein (arrow).

Anti-FKSG80 / GPR81 Antibody (Arg203, FITC) - LS-C243950 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-FKSG80 / GPR81 Antibody (Arg203, PE) - LS-C243951 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-FKSG80 / GPR81 Antibody (aa207-220) - LS-C112795 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
GPR81 antibody (0.5 ug/ml) staining of Human Liver lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-FKSG80 / GPR81 Antibody (Ser296, PE) - LS-C243955 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FKSG80 / GPR81 Antibody (Cys7, Azide-free, HRP) - LS-C247490 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-FKSG80 / GPR81 Antibody (Azide-free, HRP) - LS-C247489 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FKSG80 / GPR81 Antibody (Ser296, Azide-free, HRP) - LS-C247493 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FKSG80 / GPR81 Antibody (Arg203, Azide-free, HRP) - LS-C247492 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
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