| Gene Symbol |
HCAR1
|
| Entrez Gene |
27198
|
| Alt Symbol |
FKSG80, GPR104, GPR81, HCA1, LACR1, TA-GPCR, TAGPCR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hydroxycarboxylic acid receptor 1
|
| Other Description |
G protein-coupled receptor 104|G protein-coupled receptor 81|G-protein coupled receptor 104|G-protein coupled receptor 81|T-cell activation G protein-coupled receptor|hydroxy-carboxylic acid receptor 1|lactate receptor 1
|
| Swissprots |
B2R9X4 Q9BXC0 Q6NXU5 Q3Y5J3 Q4VBN1
|
| Accessions |
AAL26481 AAZ67915 BAB89344 BAC06084 EAW98337 Q9BXC0 AF345568 AAK29071 AF385431 AAM43832 AF385432 AAM43833 AK122659 AK289557 BAF82246 AK313955 BAG36671 AY507143 AAR92485 BC066881 AAH66881 BC066882 AAH66882 BC066883 AAH66883 BC067484 AAH67484 BC095506 AAH95506 EU809458 ACJ03844 GQ129267 ACT64401 GQ129268 ACT64402 NM_032554 NP_115943
|
| Function |
Acts as a receptor for L-lactate and mediates its anti- lipolytic effect through a G(i)-protein-mediated pathway. {ECO:0000269|PubMed:19047060}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed abundantly in brown and white fat. It also detectable at lower levels in liver, kidney, skeletal muscle, brain and pituitary. Not detected in frontal, temporal and occipital lobes of the cortex, basal forebrain, caudate nucleus, nucleus accumbens and hippocampus. {ECO:0000269|PubMed:11574155, ECO:0000269|PubMed:19047060}.
|
| Top Pathways |
cAMP signaling pathway
|